Hepatitis B virus PRE alpha
The Hepatitis B virus PRE stem-loop alpha (HBV PRE SL alpha) is an RNA structure that is shown to play a role in nuclear export of HBV mRNAs.
| Hepatitis B virus PRE alpha | |
|---|---|
| Identifiers | |
| Symbol | HBV_PREalpha |
| Rfam | HBV_PREalpha |
| Other data | |
| RNA type | Cis-reg; |
| PDB structures | PDBe |
HBV PREalpha consists of a 30 nt stem-loop, with a 5 nt apical loop. The conserved stem-loop was predicted within the HBV PRE sequence and confirmed by mutagenesis.[1][2][3]
The exact role of this structure in nuclear export has not yet been determined.[4]
See also
References
- Smith Gj, 3rd; Donello, JE; Lück, R; Steger, G; Hope, TJ (1998). "The hepatitis B virus post-transcriptional regulatory element contains two conserved RNA stem-loops which are required for function". Nucleic Acids Research. 26 (21): 4818–4827. doi:10.1093/nar/26.21.4818. PMC 147918. PMID 9776740.
- Schwalbe, M; Ohlenschläger, O; Marchanka, A; Ramachandran, R; Häfner, S; Heise, T; Görlach, M (March 2008). "Solution structure of stem-loop alpha of the hepatitis B virus post-transcriptional regulatory element". Nucleic Acids Research. 36 (5): 1681–1689. doi:10.1093/nar/gkn006. PMC 2275152. PMID 18263618.
- Lim, CS; Brown, CM (September 2016). "Hepatitis B virus nuclear export elements: RNA stem-loop α and β, key parts of the HBV post-transcriptional regulatory element". RNA biology. 13 (9): 743–747. doi:10.1080/15476286.2016.1166330. PMC 5013995. PMID 27031749.
- Chen, A; Panjaworayan T-Thienprasert, N; Brown, CM (7 July 2014). "Prospects for inhibiting the post-transcriptional regulation of gene expression in hepatitis B virus". World Journal of Gastroenterology. 20 (25): 7993–8004. doi:10.3748/wjg.v20.i25.7993. PMC 4081668. PMID 25009369.
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