Heinz Wiendl

Heinz Wiendl (born 1968 in Rötz) is a German neurologist and professor at the University Hospital Muenster. He is known for his works in the field of nervous system inflammation and multiple sclerosis.

Biography

Wiendl studied psychology and medicine from 1989 to 1996 at the University of Erlangen-Nuremberg, Germany, Duke University, North Carolina, and Bale University, Switzerland. He did his MD in 1996. He was a scholar of the German Research Council (Deutsche Forschungsgemeinschaft) at the Max Planck Institute of Neurobiology (Martinsried), worked as a clinical and research fellow at the Department of Neurology Tuebingen, received board certification (2004) and completed his habilitation (2004). In 2005 he was appointed as a professor of neurology and head of the clinical research group for MS and neuroimmunology in Wuerzburg and acted as a vice-chair of the Department of Neurology. In 2010 he was recruited to the University of Muenster, where he accepted the position as a director of the Department of Neurology – Inflammatory Diseases of the Nervous System and Neurooncology. Since 1 May 2013 he is director of the Department of Neurology in Muenster.[1]

Scientific contribution

Wiendl’s clinical and scientific work focusses on inflammatory diseases of the nervous system. Taking multiple sclerosis as an exemplary disease, he primarily investigates aspects of immuneregulation and the interaction between immune system and nervous system. Furthermore, Wiendl conducted research projects on immune cell trafficking[2][3] and explores biomarkers for the prognosis and therapy of multiple sclerosis.[4][5] By establishing translational research projects, his work helps to further elucidate the question of how immune therapies in neurological diseases work and how new mechanisms of action can be developed. In his research projects, Wiendl pursues a translational approach, closely connecting laboratory work with patient care. With this objective, he also established a biobank at the Department of Neurology Muenster. Wiendl was involved in the development of the monoclonal antibody daclizumab[6] which was approved in 2016 and exhibits a completely new mechanism of action in MS therapy. Heinz Wiendl is member of the steering committee of the excellence cluster cells in motion (CiM), funded by the German federal government.

Academic memberships

Wiendl is a member in the following academic societies: American Academy of Neurology (AAN), International Society of Neuroimmunology (ISNI),[7] Editorial Board of the Public Library of Science (PLoS) ONE.

Honors and awards
  • 2015 Sobek award for MS research of the German Society of Multiple Sclerosis (DMSG)
  • 2004 Sobek award for MS research (young scientists’ award) of the German Society of Multiple Sclerosis (DMSG)[8]

Publications

Wiendl published more than 350 scientific works and reviews, books, book chapters and monographies (as of October 2016).

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References
  1. "Heinz Wiendl CV" (PDF). Archived from the original (PDF) on 2016-10-24. Retrieved 2016-11-27.
  2. Klotz L, Kuzmanov I, Hucke S, Gross CC, Posevitz V, Dreykluft A, Schulte-Mecklenbeck A, Janoschka C, Lindner M, Herold M, Schwab N, Ludwig-Portugall I, Kurts C, Meuth SG, Kuhlmann T, Wiendl H. B7-H1 shapes T-cell-mediated brain endothelial cell dysfunction and regional encephalitogenicity in spontaneous CNS autoimmunity. Proc Natl Acad Sci U S A. 2016. [Epub ahead of print]
  3. Gross CC, Schulte-Mecklenbeck A, Rünzi A, Kuhlmann T, Posevitz-Fejfár A, Schwab N, Schneider-Hohendorf T, Herich S, Held K, Konjević M, Hartwig M, Dornmair K, Hohlfeld R, Ziemssen T, Klotz L, Meuth SG, Wiendl H. Impaired NK-mediated regulation of T-cell activity in multiple sclerosis is reconstituted by IL-2 receptor modulation. Proc Natl Acad Sci U S A. 2016;113(21):E2973-82.
  4. Schneider-Hohendorf T, Rossaint J, Mohan H, Böning D, Breuer J, Kuhlmann T, Gross CC, Flanagan K, Sorokin L, Vestweber D, Zarbock A, Schwab N, Wiendl H. VLA-4 blockade promotes differential routes into human CNS involving PSGL-1 rolling of T cells and MCAM-adhesion of T(H)17 cells. J Exp Med. 2014;211:1833–46
  5. Schwab N, Schneider-Hohendorf T, Posevitz V, Breuer J, Göbel K, Windhagen S, Brochet B, Vermersch P, Lebrun-Frenay C, Posevitz-Fejfar A, Capra R, Imberti L, Straeten V, Haas J, Wildemann B, Havla J, Kümpfel T, Meinl I, Niessen K, Gölz S, Kleinschnitz C, Warnke C, Buck D, Gold R, Kieseier BC, Meuth SG, Foley J, Chan A, Brassat D, Wiendl H. L-selectin is a possible biomarker for individual PML risk in natalizumab-treated MS patients. Neurology. 2013;81:865-71
  6. Kappos L, Wiendl H, Selmaj K, Arnold DL, Havrdova E, Boyko A, Kaufman M, Rose J, Greenberg S, Sweetser M, Riester K, O'Neill G, Elkins J. Daclizumab HYP versus Interferon Beta-1a in Relapsing Multiple Sclerosis. N Engl J Med. 2015;373(15):1418–28.
  7. Wiendl, Heinz at the International Society of Neuroimmunology – ISNI
  8. "Heinz Wiendl receives European highest remunerated research price for multiple sclerosis". Archived from the original on 2016-11-27. Retrieved 2016-11-27.
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