Heat-responsive protein 12

Ribonuclease UK114 is an enzyme that in humans is encoded by the HRSP12 gene.[5][6][7]

RIDA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1ONI
Identifiers
Aliases	RIDA, P14.5, PSP, UK114, HRSP12, Heat-responsive protein 12, reactive intermediate imine deaminase A homolog, hp14.5
External IDs	OMIM: 602487 MGI: 1095401 HomoloGene: 4261 GeneCards: RIDA
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q22.2 Start 98,102,344 bp[1] End 98,117,171 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 B3.1 Start 34,484,021 bp[2] End 34,495,255 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein homodimerization activity • ion binding • long-chain fatty acid binding • transition metal ion binding • hydrolase activity • RNA binding • deaminase activity • endoribonuclease activity, producing 3'-phosphomonoesters Cellular component • cytosol • mitochondrion • extracellular exosome • cell nucleus • cytoplasm • mitochondrial matrix • peroxisome Biological process • kidney development • lung development • G1 to G0 transition • response to lipid • brain development • response to salt • negative regulation of epithelial cell proliferation • RNA phosphodiester bond hydrolysis, endonucleolytic • organonitrogen compound catabolic process • negative regulation of translation • L-threonine catabolic process to glycine Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10247	15473
Ensembl	ENSG00000132541	ENSMUSG00000022323
UniProt	P52758	P52760
RefSeq (mRNA)	NM_005836	NM_008287
RefSeq (protein)	NP_005827	NP_032313
Location (UCSC)	Chr 8: 98.1 – 98.12 Mb	Chr 15: 34.48 – 34.5 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000132541 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022323 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Schmiedeknecht G, Kerkhoff C, Orso E, Stohr J, Aslanidis C, Nagy GM, Knuechel R, Schmitz G (Jan 1997). "Isolation and characterization of a 14.5-kDa trichloroacetic-acid-soluble translational inhibitor protein from human monocytes that is upregulated upon cellular differentiation". Eur J Biochem. 242 (2): 339–51. doi:10.1111/j.1432-1033.1996.0339r.x. PMID 8973653.
6. Schmiedeknecht G, Buchler C, Schmitz G (Jan 1998). "A bidirectional promoter connects the p14.5 gene to the gene for RNase P and RNase MRP protein subunit hPOP1". Biochem Biophys Res Commun. 241 (1): 59–67. doi:10.1006/bbrc.1997.7772. PMID 9405234.
7. "Entrez Gene: HRSP12 heat-responsive protein 12".

Further reading

• Mistiniene E, Pozdniakovaite N, Popendikyte V, Naktinis V (2006). "Structure-based ligand binding sites of protein p14.5, a member of protein family YER057c/YIL051c/YjgF". Int. J. Biol. Macromol. 37 (1–2): 61–8. doi:10.1016/j.ijbiomac.2005.08.008. PMID 16198412.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Manjasetty BA, Delbrück H, Pham DT, et al. (2004). "Crystal structure of Homo sapiens protein hp14.5". Proteins. 54 (4): 797–800. doi:10.1002/prot.10619. PMID 14997576.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kanouchi H, Oka T, Asagi K, et al. (2000). "Expression and cellular distribution of perchloric acid-soluble protein is dependent on the cell-proliferating states of NRK-52E cells". Cell. Mol. Life Sci. 57 (7): 1103–8. doi:10.1007/PL00000746. PMID 10961346.
• Morishita R, Kawagoshi A, Sawasaki T, et al. (1999). "Ribonuclease activity of rat liver perchloric acid-soluble protein, a potent inhibitor of protein synthesis". J. Biol. Chem. 274 (29): 20688–92. doi:10.1074/jbc.274.29.20688. PMID 10400702.
• Colombo I, Ceciliani F, Ronchi S, et al. (1998). "cDNA cloning and Escherichia coli expression of UK114 tumor antigen". Biochim. Biophys. Acta. 1442 (1): 49–59. doi:10.1016/s0167-4781(98)00120-1. PMID 9767104.
• Racca S, Di Carlo F, Bartorelli A, et al. (1998). "Growth inhibition of DMBA-induced rat mammary carcinomas by UK 114". Virchows Arch. 431 (5): 323–8. doi:10.1007/s004280050106. PMID 9463573.
• Oka T, Tsuji H, Noda C, et al. (1996). "Isolation and characterization of a novel perchloric acid-soluble protein inhibiting cell-free protein synthesis". J. Biol. Chem. 270 (50): 30060–7. doi:10.1074/jbc.270.50.30060. PMID 8530410.

External links

• HRSP12 human gene location in the UCSC Genome Browser.
• HRSP12 human gene details in the UCSC Genome Browser.