Hassall's corpuscles

Hassall's corpuscles (or thymic corpuscles (bodies)) are structures found in the medulla of the human thymus, formed from eosinophilic type VI epithelial reticular cells arranged concentrically. These concentric corpuscles are composed of a central mass, consisting of one or more granular cells, and of a capsule formed of epithelioid cells. They vary in size with diameters from 20 to more than 100μm, and tend to grow larger with age.[1] They can be spherical or ovoid and their epithelial cells contain keratohyalin and bundles of cytoplasmic fibres.[2] Later studies indicate that Hassall's corpuscles differentiate from medullary thymic epithelial cells after they lose autoimmune regulator (AIRE) expression.[3] They are named for Arthur Hill Hassall, who discovered them in 1846.[4][5]

Hassall's corpuscles
Micrograph of a thymic corpuscle. H&E stain.
Details
Part ofMedulla of thymus
Anatomical terminology

The function of Hassall's corpuscles is currently unclear, and the absence of this structure in the murine thymus has restricted mechanistic dissection. It is known that Hassall's corpuscles are a potent source of the cytokine TSLP. In vitro, TSLP directs the maturation of dendritic cells, and increases the ability of dendritic cells to convert naive thymocytes to a Foxp3+ regulatory T cell lineage.[6][7] It is unknown if this is the physiological function of Hassall's corpuscles in vivo.

Research into the systemic organization of Hassall's corpuscles in the thymus of first-year children has determined that the corpuscles' main cells are two types of cells that differ from each other in origin, texture, function, immunohistochemical and ultrastructural features. The composition and number of accessory cells in Hassall's corpuscles depends on their stage of development. The main systemic factor of corpuscle organization is the process of synthesis, mobilization, and transduction of tissue-specific autoantigens for immune tolerance induction.[8]

In the past decade, researchers found tissue-specific self-antigens in Hassall's corpuscles and revealed their role in the pathogenesis of diseases such as type 1 diabetes, rheumatoid arthritis, multiple sclerosis, autoimmune thyroiditis, Goodpasture's syndrome, and others. They also discovered that Hassall's corpuscles synthesize chemokines affecting different cell populations in thymic medulla. Despite this, the information on the relationship between Hassall's corpuscles with other cell types of thymic medulla (dendritic, myoid, neuroendocrine cells, thymocytes, macrophages, eosinophils, etc.) remains insufficient and often contradictory. Mechanisms of these relationships and their functional significance are still unclear. The lack of such data does not allow a systemic view of the differentiation processes in the thymus.

References

This article incorporates text in the public domain from page 1274 of the 20th edition of Gray's Anatomy (1918)

  1. Geneser, Finn (1999). Histologi. Munksgaard Danmark. ISBN 87-628-0137-6.
  2. Dorland's (2012). Dorland's Illustrated Medical Dictionary (32nd ed.). Elsevier. p. 419. ISBN 978-1-4160-6257-8.
  3. Wang, Xiaoping; et al. (2012). "Post-Aire maturation of thymic medullary epithelial cells involves selective expression of keratinocyte-specific autoantigens". Front. Immunol. 3 (March): 19. doi:10.3389/fimmu.2012.00019. PMC 3310317. PMID 22448160.
  4. Louis Kater: A Note on Hassall's Corpuscles. Contemporary Topics in Immunobiology Volume 2, 1973, pp. 101-109.
  5. Hassall, A. H., 1846. Microscopic Anatomy of the Human Body in Health and Disease, Highly, London.
    • Watanabe N, Wang Y, Lee H, Ito T, Wang Y, Cao W, Liu Y (2005). "Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus". Nature. 436 (7054): 1181–5. Bibcode:2005Natur.436.1181W. doi:10.1038/nature03886. PMID 16121185.
  7. "Old mystery solved, revealing origin of regulatory T cells that 'police' and protect the body"
  8. Beloveshkin, Andrei (2014). Systemic organization of Hassall's corpuscles. Medisont. ISBN 978-985-7085-22-4.
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