Harmalol

Harmalol
Names
	IUPAC name 1-Methyl-4,9-dihydro-3H-β-carbolin-7-ol
Identifiers
CAS Number	525-57-5 ;
3D model (JSmol)	Interactive image;
ChemSpider	11262879;
ECHA InfoCard	100.007.616
EC Number	208-375-4;
PubChem CID	5353656;
UNII	2NQN80556Q ;
CompTox Dashboard (EPA)	DTXSID90975692 DTXSID50894870, DTXSID90975692 ;
	InChI InChI=1S/C12H12N2O/c1-7-12-10(4-5-13-7)9-3-2-8(15)6-11(9)14-12/h2-3,6,14-15H,4-5H2,1H3 Key: RHVPEFQDYMMNSY-UHFFFAOYSA-N;
	SMILES OC1=CC=C(C(CCN=C3C)=C3N2)C2=C1;
Properties
Chemical formula	C12H12N2O
Molar mass	200.241 g·mol−1
Appearance	Red solid
Melting point	100 to 105 °C (212 to 221 °F; 373 to 378 K) (trihydrate)[1]
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	Infobox references

Harmalol is a bioactive beta-carboline and a member of the harmala alkaloids.[2][3]

Legal status

Australia

Harmala alkaloids are considered Schedule 9 prohibited substances under the Poisons Standard (October 2015).[4] A Schedule 9 substance is a substance which may be abused or misused, the manufacture, possession, sale or use of which should be prohibited by law except when required for medical or scientific research, or for analytical, teaching or training purposes with approval of Commonwealth and/or State or Territory Health Authorities.[4]

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References

Thieme Chemistry (Hrsg.): RÖMPP Online – Version 3.37. Georg Thieme Verlag KG, Stuttgart, 27. September 2013.
Sarkar S, Bhadra K (2014). "Binding of alkaloid harmalol to DNA: photophysical and calorimetric approach". J Photochem Photobiol B. 130: 272–80. doi:10.1016/j.jphotobiol.2013.11.021. PMID 24368411.
El Gendy MA, Soshilov AA, Denison MS, El-Kadi AO (2012). "Harmaline and harmalol inhibit the carcinogen-activating enzyme CYP1A1 via transcriptional and posttranslational mechanisms". Food Chem Toxicol. 50 (2): 353–62. doi:10.1016/j.fct.2011.10.052. PMC 3281145. PMID 22037238.
Poisons Standard October 2015 https://www.comlaw.gov.au/Details/F2015L01534

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[1] Thieme Chemistry (Hrsg.): RÖMPP Online – Version 3.37. Georg Thieme Verlag KG, Stuttgart, 27. September 2013.

[pmid24368411-2] Sarkar S, Bhadra K (2014). "Binding of alkaloid harmalol to DNA: photophysical and calorimetric approach". J Photochem Photobiol B. 130: 272–80. doi:10.1016/j.jphotobiol.2013.11.021. PMID 24368411.

[pmid22037238-3] El Gendy MA, Soshilov AA, Denison MS, El-Kadi AO (2012). "Harmaline and harmalol inhibit the carcinogen-activating enzyme CYP1A1 via transcriptional and posttranslational mechanisms". Food Chem Toxicol. 50 (2): 353–62. doi:10.1016/j.fct.2011.10.052. PMC 3281145. PMID 22037238.

[Poisons_Standard-4] Poisons Standard October 2015 https://www.comlaw.gov.au/Details/F2015L01534