Hanneke Jansen

Johanna Maria "Hanneke" Jansen is a computational chemistry leader working at Novartis on multiple drug targets. She previously worked at Astra and at Chiron Corporation.[1]

Johanna M. Jansen, Ph.D.
Other namesHanneke
Alma materRijksuniversiteit Groningen, Uppsala University
Websitehttps://www.novartis.com/our-science/postdoc-program/leadership/johanna-hanneke-jansen-phd

Education

Jansen received her doctoral degree from the University of Groningen (The Netherlands) in 1995, studying computational medicinal chemistry. Her dissertation topic[2] concerned 3D modeling of the melatonin receptor, including work on synthesizing and separating analytes[3][4] to probe its chemistry. She completed a postdoctoral fellowship at Uppsala University in 1997. Her work there related to modeling receptor interactions[5] of drug leads to judge their serotonergic or dopaminergic activities.

Research

Much of Jansen's oeuvre uses in silico methods to study receptor biology, drug design, and drug-protein interactions. An early study (2000) while she was employed at Chiron looked at conformations of the anti-cancer treatment Taxol in nonpolar environments.[6]

In a 2012 commentary for Future Medicinal Chemistry, Jansen led a team of distinguished computational chemists in a call to action, namely that standardized data sets be used across the industry, and that sharing program code between groups at different companies and institutions should be mandated.[7]

A 2017 open-access study in PLoS One related some of Novartis' work - spearheaded by Jansen - to study the oncogenic protein RAS through inhibitors that targeted its inactive conformations.[8]

Volunteer service

Jansen has served the ACS division on Computers in Chemistry since at least 2007, holding multiple leadership positions.[9][10] Outside of pharmaceutical work, she is perhaps best known as a co-Founder and Steering Committee member for the Teach-Discover-Treat initiative,[11] which creates challenges for students and young professionals to design drugs against neglected diseases such as malaria or Trypanosoma using computational chemistry shared data sets and screens.

Awards
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References
  1. "Johanna (Hanneke) Jansen, Ph.D. | Novartis". Novartis. Retrieved 2018-12-01.
  2. "Three dimensions in drug design". www.bibliotheek.nl (in Dutch). Retrieved 2018-12-01.
  3. Jansen, Johanna M.; Copinga, Swier; Gruppen, Gert; Isaksson, Roland; Witte, Dirk T.; Grol, Cor J. (1994). "Semipreparative enantiomeric separation of a series of putative melatonin receptor agents using tri-acetylcellulose as chiral stationary phase". Chirality. 6 (7): 596–604. doi:10.1002/chir.530060714. ISSN 0899-0042. PMID 7986673.
  4. Witte, Dirk T.; Bruggeman, Frank J.; Franke, Jan Piet; Copinga, Swier; Jansen, Johanna M.; De Zeeuw, Rokus A. (1993). "Comparison between cellulose and amylose tris(3,5-dimethylphenylcarbamate) chiral stationary phases for enantiomeric separation of 17 amidotetralins". Chirality. 5 (7): 545–553. doi:10.1002/chir.530050711. ISSN 0899-0042.
  5. Hedberg, Martin H.; Linnanen, Tero; Jansen, Johanna M.; Nordvall, Gunnar; Hjorth, Stephan; Unelius, Lena; Johansson, Anette M. (January 1996). "11-Substituted (R)-Aporphines: Synthesis, Pharmacology, and Modeling of D2Aand 5-HT1AReceptor Interactions". Journal of Medicinal Chemistry. 39 (18): 3503–3513. doi:10.1021/jm960189i. ISSN 0022-2623. PMID 8784448.
  6. Snyder, James P.; Nevins, Neysa; Cicero, Daniel O.; Jansen, Johanna (February 2000). "The Conformations of Taxol in Chloroform" (PDF). Journal of the American Chemical Society. 122 (4): 724–725. doi:10.1021/ja9930115. hdl:2108/87943. ISSN 0002-7863.
  7. Jansen, Johanna M; Amaro, Rommie E; Cornell, Wendy; Tseng, Y Jane; Walters, W Patrick (October 2012). "Computational chemistry and drug discovery: a call to action". Future Medicinal Chemistry. 4 (15): 1893–1896. doi:10.4155/fmc.12.137. ISSN 1756-8919. PMID 23088271.
  8. Jansen, Johanna M.; Wartchow, Charles; Jahnke, Wolfgang; Fong, Susan; Tsang, Tiffany; Pfister, Keith; Zavorotinskaya, Tatiana; Bussiere, Dirksen; Cheng, Jan Marie (2017-04-06). "Inhibition of prenylated KRAS in a lipid environment". PLOS ONE. 12 (4): e0174706. Bibcode:2017PLoSO..1274706J. doi:10.1371/journal.pone.0174706. ISSN 1932-6203. PMC 5383040. PMID 28384226.
  9. Solutions, Allen Richon, Molecular. "2007 Officers for COMP". oldwww.acscomp.org. Retrieved 2018-12-01.
  10. "Officers in Past Years - ACS COMP Division". www.acscomp.org. Retrieved 2018-12-01.
  11. "Teach-Discover-Treat". www.teach-discover-treat.org. Retrieved 2018-12-01.
  12. "2011 ACS Fellows - American Chemical Society". American Chemical Society. Retrieved 2018-12-01.
  13. "Awards - ACS COMP Division". web2011.acscomp.org. Retrieved 2018-12-01.
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