Halorubrum pleomorphic virus 1

Halorubrum pleomorphic virus 1 is a single stranded DNA virus that infects the species of the archaeal genus Halorubrum.[1] It is unlike any other known virus infecting the archaea with a single stranded DNA genome and an external lipid envelope and is classified in the family Pleolipoviridae, genus Alphapleolipovirus, species Halorubrum virus HRPV1.[2]

Halorubrum pleomorphic virus 1
Virus classification
Group:
Group II (ssDNA)
Family:
Pleolipoviridae
Genus:
Alphapleolipovirus

Virology

The virons are pleomorphic is shape with an external lipd envelope. There are two main structural proteins (VP3 and VP4) of molecular weights 15 and 53 kiloDaltons respectively. The genome does not appear to be associated with a nucleoprotein.

The spike protein (VP4) is glycosylated. The lipid envelope is similar to its host's composition. VP3 is a membrane protein that does not appears to be exposed to the external environment. It may be organised to form a shell around the genome as is the case in other viruses but this is not yet known.

This virus infects members of the genus Halorubrum. Infection appears to be productive without lysis of the host like may of the archaeal viruses. Exit is likely to be by budding from the cell membrane.

Genome

The genome is a single stranded DNA molecule 7048 bases in length. It encodes nine open reading frames. Two of these encode the structural proteins VP3 and VP4. Another (VP8) seems likely to be an ATPase. The functions of the remaining proteins is not known.

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References
  1. Pietila, M, Laurinavicius S, Sund, J, Roine E & Bamford D (2009) The single-stranded DNA genome of novel archaeal virus Halorubrum pleomorphic virus 1 Is enclosed in the envelope decorated with glycoprotein spikes. J Virol 84 (2) 788-798 doi:10.1128/JVI.01347-09
  2. "ICTV Online (10th) Report Pleolipoviridae".
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