HYAL3

Hyaluronidase-3 is an enzyme that in humans is encoded by the HYAL3 gene.[5][6]

HYAL3
Identifiers
Aliases	HYAL3, HYAL-3, LUCA-3, LUCA3, hyaluronoglucosaminidase 3, hyaluronidase 3
External IDs	OMIM: 604038 MGI: 1330288 HomoloGene: 2626 GeneCards: HYAL3
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p21.31 Start 50,292,831 bp[1] End 50,299,405 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 F1|9 58.19 cM Start 107,580,818 bp[2] End 107,587,359 bp[2]
Gene ontology Molecular function • hydrolase activity, acting on glycosyl bonds • GO:0001948 protein binding • hyaluronoglucuronidase activity • hydrolase activity • catalytic activity • hyalurononglucosaminidase activity Cellular component • extracellular region • Acrosome • acrosomal membrane • lysosome • endosome • early endosome • endoplasmic reticulum • cell membrane • membrane • cytoplasmic vesicle • sperm midpiece Biological process • cellular response to UV-B • cartilage development • response to antibiotic • cellular response to tumor necrosis factor • metabolism • cellular response to interleukin-1 • inflammatory response • hyaluronan catabolic process • carbohydrate metabolic process • response to virus • ovarian follicle atresia • single fertilization • penetration of zona pellucida • negative regulation of ovarian follicle development • positive regulation of acrosomal vesicle exocytosis • viral entry Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8372	109685
Ensembl	ENSG00000186792	ENSMUSG00000036091
UniProt	O43820	Q8VEI3
RefSeq (mRNA)	NM_003549 NM_001200029 NM_001200030 NM_001200031 NM_001200032	NM_178020
RefSeq (protein)	NP_001186958 NP_001186959 NP_001186960 NP_001186961 NP_003540	NP_821139
Location (UCSC)	Chr 3: 50.29 – 50.3 Mb	Chr 9: 107.58 – 107.59 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a protein which is similar in structure to hyaluronidases. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. However, this protein has not yet been shown to have hyaluronidase activity. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000186792 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000036091 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Csoka AB, Scherer SW, Stern R (Nov 1999). "Expression analysis of six paralogous human hyaluronidase genes clustered on chromosomes 3p21 and 7q31". Genomics. 60 (3): 356–61. doi:10.1006/geno.1999.5876. PMID 10493834.
6. "Entrez Gene: HYAL3 hyaluronoglucosaminidase 3".

Further reading

• Muzny DM, Scherer SE, Kaul R, et al. (2006). "The DNA sequence, annotation and analysis of human chromosome 3". Nature. 440 (7088): 1194–8. doi:10.1038/nature04728. PMID 16641997.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Junker N, Latini S, Petersen LN, Kristjansen PE (2003). "Expression and regulation patterns of hyaluronidases in small cell lung cancer and glioma lines". Oncol. Rep. 10 (3): 609–16. doi:10.3892/or.10.3.609. PMID 12684632.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Lokeshwar VB, Schroeder GL, Carey RI, et al. (2002). "Regulation of hyaluronidase activity by alternative mRNA splicing". J. Biol. Chem. 277 (37): 33654–63. doi:10.1074/jbc.M203821200. PMID 12084718.
• Shuttleworth TL, Wilson MD, Wicklow BA, et al. (2002). "Characterization of the murine hyaluronidase gene region reveals complex organization and cotranscription of Hyal1 with downstream genes, Fus2 and Hyal3". J. Biol. Chem. 277 (25): 23008–18. doi:10.1074/jbc.M108991200. PMID 11929860.
• Triggs-Raine B, Salo TJ, Zhang H, et al. (1999). "Mutations in HYAL1, a member of a tandemly distributed multigene family encoding disparate hyaluronidase activities, cause a newly described lysosomal disorder, mucopolysaccharidosis IX". Proc. Natl. Acad. Sci. U.S.A. 96 (11): 6296–300. doi:10.1073/pnas.96.11.6296. PMC 26875. PMID 10339581.