HSPB7

Heat Shock Protein Family B (small) member 7 (HSPB7) in humans is a protein encoded by a gene of the same name with four exons that is located on chromosome 1p36.13.[4],[5]. HSPB7 contains 170 amino acids and has a molecular weight of 18,611Da [6]. HSPB7 is a member of human small heat shock protein (HSPB) family, which contains eleven family members of chaperone proteins [7]. HSPB7 and its gene pair SRARP are located 5 kb apart on the opposite strands of chromosome 1p36.13 [8].

HSPB7
Identifiers
AliasesHSPB7, cvHSP, heat shock protein family B (small) member 7
External IDsOMIM: 610692 MGI: 1352494 HomoloGene: 8480 GeneCards: HSPB7
Orthologs
SpeciesHumanMouse
Entrez

27129

29818

Ensembl

n/a

ENSMUSG00000006221

UniProt

Q9UBY9

P35385

RefSeq (mRNA)

NM_014424

NM_013868

RefSeq (protein)

NP_038896

Location (UCSC)n/aChr 4: 141.42 – 141.43 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Expression and molecular function

HSPB7 is widely expressed throughout the body and its highest expression is observed in the cardiac tissue [7], [9]. HSPB protein family, including HSPB7, act protectively on aggregation of several proteins containing an extended polyglutamine (polyQ) stretch that are linked to a variety of neurodegenerative diseases [10]. Among these proteins, HSPB7 is the most potent polyQ aggregation suppressor within the HSPB family of chaperones [10]. In addition, HSPB7 protein contains a HSP20 domain and strongly interacts with the chaperone protein 14-3-3 [8]. An interaction with the 14-3-3 protein is a common molecular feature between HSPB7 and SRARP proteins [8],[11]

Role in cardiomyopathy and Cancer

HSPB7 has cardiac protective functions and mutations in this gene leads to cardiomyopathies [10]. It has been suggested that HSPB7 cardioprotective function is mediated by facilitating sarcomeric proteostasis [12]. Furthermore, HSPB7 is widely inactivated in malignancies by copy-number loss and epigenetic silencing and the overexpression of this protein results in a tumor suppressor function in multiple cancer cell lines [8], [13]. The overexpression of HSPB7 and its gene pair SRARP lead to a reduction in the relative phosphorylation and/or expression of Akt and ERK in cancer cells [8]. In addition, it has been suggested that HSBP7 is regulated by p53 tumor suppressor in renal cell carcinoma [13].

Approved SymbolHSPB7
Approved NameHeat shock protein family B (small) member 7
HGNC IDHGNC:5249
Previous nameheat shock 27kD protein family, member 7 (cardiovascular)
Alias SymbolscvHSP
Chromosome location1p36.13
EnsemblENSG00000173641
UniProtQ9UBY9
NCBI Gene27129
RefSeqNM_014424
UCSCuc001axo.2
Protein SequenceHSPB7 Protein Sequence (Ensembl)
WikidataQ18038659
PubMedHSPB7 PubMed References


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References
  1. GRCm38: Ensembl release 89: ENSMUSG00000006221 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "HSPB7". HUGO Gene Nomenclature Committee.
  5. "HSPB7 heat shock protein family B (small) member 7 [ Homo sapiens (human)]". The National Center for Biotechnology Information.
  6. "HSPB7_HUMAN". UniProt.
  7. Mj, Vos; B, Kanon; Hh, Kampinga (August 2009). "HSPB7 Is a SC35 Speckle Resident Small Heat Shock Protein". Biochimica et biophysica acta. PMID 19464326. Retrieved 2020-05-30.
  8. A, Naderi (May 2018). "SRARP and HSPB7 Are Epigenetically Regulated Gene Pairs That Function as Tumor Suppressors and Predict Clinical Outcome in Malignancies". Molecular oncology. doi:10.1002/1878-0261.12195. PMC 5928383. PMID 29577611.
  9. Wu, Tongbin; Mu, Yongxin; Bogomolovas, Julius; Fang, Xi; Veevers, Jennifer; Nowak, Roberta B.; Pappas, Christopher T.; Gregorio, Carol C.; Evans, Sylvia M.; Fowler, Velia M.; Chen, Ju (2017-11-07). "HSPB7 is indispensable for heart development by modulating actin filament assembly". Proceedings of the National Academy of Sciences. 114 (45): 11956–11961. doi:10.1073/pnas.1713763114. ISSN 0027-8424. PMC 5692592. PMID 29078393.
  10. Mj, Vos; Mp, Zijlstra; B, Kanon; Ma, van Waarde-Verhagen; Er, Brunt; Hm, Oosterveld-Hut; S, Carra; Oc, Sibon; Hh, Kampinga (2010-12-01). "HSPB7 Is the Most Potent polyQ Aggregation Suppressor Within the HSPB Family of Molecular Chaperones". Human molecular genetics. PMID 20843828. Retrieved 2020-05-30.
  11. A, Naderi (2017-05-11). "C1orf64 Is a Novel Androgen Receptor Target Gene and Coregulator That Interacts With 14-3-3 Protein in Breast Cancer". Oncotarget. doi:10.18632/oncotarget.17826. PMC 5593696. PMID 28915724. Retrieved 2020-05-30.
  12. Ej, Mercer; Yf, Lin; L, Cohen-Gould; T, Evans (2018-03-01). "Hspb7 Is a Cardioprotective Chaperone Facilitating Sarcomeric Proteostasis". Developmental biology. doi:10.1016/j.ydbio.2018.01.005. PMC 5818303. PMID 29331499. Retrieved 2020-05-30.
  13. J, Lin; Z, Deng; C, Tanikawa; T, Shuin; T, Miki; K, Matsuda; Y, Nakamura (May 2014). "Downregulation of the Tumor Suppressor HSPB7, Involved in the p53 Pathway, in Renal Cell Carcinoma by Hypermethylation". International journal of oncology. doi:10.3892/ijo.2014.2314. PMC 4027944. PMID 24585183. Retrieved 2020-05-30.
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