HSPB2

Heat shock protein beta-2 is a protein that in humans is encoded by the HSPB2 gene.[4][5][6]

HSPB2
Identifiers
Aliases	HSPB2, HSP27, Hs.78846, LOH11CR1K, MKBP, heat shock protein family B (small) member 2
External IDs	OMIM: 602179 MGI: 1916503 HomoloGene: 68189 GeneCards: HSPB2
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q23.1 Start 111,912,734 bp[1] End 111,914,093 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0010577 enzyme activator activity • GO:0001948 protein binding Cellular component • cytoplasm • cytosol • cell nucleus Biological process • response to unfolded protein • GO:0048554 positive regulation of catalytic activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3316	69253
Ensembl	ENSG00000170276	n/a
UniProt	Q16082	Q99PR8
RefSeq (mRNA)	NM_001541	NM_001164708 NM_024441
RefSeq (protein)	NP_001532	NP_001158180.1 NP_077761.3
Location (UCSC)	Chr 11: 111.91 – 111.91 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

HSPB2 has been shown to interact with:

• CRYAB,[7]
• HSPB8,[8][9]
• Myotonic dystrophy protein kinase[5][7] and
• TRAF6.[10]

References

1. GRCh38: Ensembl release 89: ENSG00000170276 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Iwaki A, Nagano T, Nakagawa M, Iwaki T, Fukumaki Y (February 1998). "Identification and characterization of the gene encoding a new member of the alpha-crystallin/small hsp family, closely linked to the alphaB-crystallin gene in a head-to-head manner". Genomics. 45 (2): 386–94. doi:10.1006/geno.1997.4956. PMID 9344664.
5. Suzuki A, Sugiyama Y, Hayashi Y, Nyu-i N, Yoshida M, Nonaka I, Ishiura S, Arahata K, Ohno S (April 1998). "MKBP, a novel member of the small heat shock protein family, binds and activates the myotonic dystrophy protein kinase". J Cell Biol. 140 (5): 1113–24. doi:10.1083/jcb.140.5.1113. PMC 2132705. PMID 9490724.
6. "Entrez Gene: HSPB2 heat shock 27kDa protein 2".
7. Sugiyama Y, Suzuki A, Kishikawa M, Akutsu R, Hirose T, Waye MM, Tsui SK, Yoshida S, Ohno S (January 2000). "Muscle develops a specific form of small heat shock protein complex composed of MKBP/HSPB2 and HSPB3 during myogenic differentiation". J. Biol. Chem. 275 (2): 1095–104. doi:10.1074/jbc.275.2.1095. PMID 10625651.
8. Sun X, Fontaine JM, Rest JS, Shelden EA, Welsh MJ, Benndorf R (January 2004). "Interaction of human HSP22 (HSPB8) with other small heat shock proteins". J. Biol. Chem. 279 (4): 2394–402. doi:10.1074/jbc.M311324200. PMID 14594798.
9. Benndorf R, Sun X, Gilmont RR, Biederman KJ, Molloy MP, Goodmurphy CW, Cheng H, Andrews PC, Welsh MJ (July 2001). "HSP22, a new member of the small heat shock protein superfamily, interacts with mimic of phosphorylated HSP27 ((3D)HSP27)". J. Biol. Chem. 276 (29): 26753–61. doi:10.1074/jbc.M103001200. PMID 11342557.
10. Wu Y, Liu J, Zhang Z, Huang H, Shen J, Zhang S, Jiang Y, Luo L, Yin Z (January 2009). "HSP27 regulates IL-1 stimulated IKK activation through interacting with TRAF6 and affecting its ubiquitination". Cell. Signal. 21 (1): 143–50. doi:10.1016/j.cellsig.2008.10.001. PMID 18950704.

Further reading

• Concannon CG, Gorman AM, Samali A (2003). "On the role of Hsp27 in regulating apoptosis". Apoptosis. 8 (1): 61–70. doi:10.1023/A:1021601103096. PMID 12510153.
• Elisei R, Weightman D, Kendall-Taylor P, Vassart G, Ludgate M (1993). "Muscle autoantigens in thyroid associated ophthalmopathy: the limits of molecular genetics". J. Endocrinol. Invest. 16 (7): 533–40. doi:10.1007/bf03348900. PMID 8227983.
• Deak M, Clifton AD, Lucocq LM, Alessi DR (1998). "Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB". EMBO J. 17 (15): 4426–41. doi:10.1093/emboj/17.15.4426. PMC 1170775. PMID 9687510.
• Sugiyama Y, Suzuki A, Kishikawa M, Akutsu R, Hirose T, Waye MM, Tsui SK, Yoshida S, Ohno S (2000). "Muscle develops a specific form of small heat shock protein complex composed of MKBP/HSPB2 and HSPB3 during myogenic differentiation". J. Biol. Chem. 275 (2): 1095–104. doi:10.1074/jbc.275.2.1095. PMID 10625651.
• Baysal BE, Willett-Brozick JE, Taschner PE, Dauwerse JG, Devilee P, Devlin B (2001). "A high-resolution integrated map spanning the SDHD gene at 11q23: a 1.1-Mb BAC contig, a partial transcript map and 15 new repeat polymorphisms in a tumour-suppressor region". Eur. J. Hum. Genet. 9 (2): 121–9. doi:10.1038/sj.ejhg.5200585. PMID 11313745.
• Nakagawa M, Tsujimoto N, Nakagawa H, Iwaki T, Fukumaki Y, Iwaki A (2001). "Association of HSPB2, a member of the small heat shock protein family, with mitochondria". Exp. Cell Res. 271 (1): 161–8. doi:10.1006/excr.2001.5362. PMID 11697892.
• Ito H, Kamei K, Iwamoto I, Inaguma Y, García-Mata R, Sztul E, Kato K (2002). "Inhibition of proteasomes induces accumulation, phosphorylation, and recruitment of HSP27 and alphaB-crystallin to aggresomes". J. Biochem. 131 (4): 593–603. doi:10.1093/oxfordjournals.jbchem.a003139. PMID 11926998.
• Boxman IL, Kempenaar J, de Haas E, Ponec M (2003). "Induction of HSP27 nuclear immunoreactivity during stress is modulated by vitamin C.". Exp. Dermatol. 11 (6): 509–17. doi:10.1034/j.1600-0625.2002.110603.x. PMID 12473058.
• Patel VM, Heinel LA, Provencio JJ, Vinall PE, Kramer MS, Rosenwasser RH (2003). "Validation of image analysis for enzyme histochemical and immunocytochemical staining". Biotechnic & Histochemistry. 77 (4): 213–21. doi:10.1080/714028196. PMID 12503731.
• Mao H, Li F, Ruchalski K, Mosser DD, Schwartz JH, Wang Y, Borkan SC (2003). "hsp72 inhibits focal adhesion kinase degradation in ATP-depleted renal epithelial cells". J. Biol. Chem. 278 (20): 18214–20. doi:10.1074/jbc.M300126200. PMID 12611892.
• Yonekura N, Yokota S, Yonekura K, Dehari H, Arata S, Kohama G, Fujii N (2003). "Interferon-gamma downregulates Hsp27 expression and suppresses the negative regulation of cell death in oral squamous cell carcinoma lines". Cell Death Differ. 10 (3): 313–22. doi:10.1038/sj.cdd.4401169. PMID 12700631.
• Kantham L, Kerr-Bayles L, Godde N, Quick M, Webb R, Sunderland T, Bond J, Walder K, Augert G, Collier G (2003). "Beacon interacts with cdc2/cdc28-like kinases". Biochem. Biophys. Res. Commun. 304 (1): 125–9. doi:10.1016/S0006-291X(03)00549-7. PMID 12705895.
• Yaglom J, O'Callaghan-Sunol C, Gabai V, Sherman MY (2003). "Inactivation of dual-specificity phosphatases is involved in the regulation of extracellular signal-regulated kinases by heat shock and hsp72". Mol. Cell. Biol. 23 (11): 3813–24. doi:10.1128/MCB.23.11.3813-3824.2003. PMC 155207. PMID 12748284.
• Park KJ, Gaynor RB, Kwak YT (2003). "Heat shock protein 27 association with the I kappa B kinase complex regulates tumor necrosis factor alpha-induced NF-kappa B activation". J. Biol. Chem. 278 (37): 35272–8. doi:10.1074/jbc.M305095200. PMID 12829720.
• Wen FC, Li YH, Tsai HF, Lin CH, Li C, Liu CS, Lii CK, Nukina N, Hsieh M (2003). "Down-regulation of heat shock protein 27 in neuronal cells and non-neuronal cells expressing mutant ataxin-3". FEBS Lett. 546 (2–3): 307–14. doi:10.1016/S0014-5793(03)00605-7. PMID 12832059.
• Parcellier A, Schmitt E, Gurbuxani S, Seigneurin-Berny D, Pance A, Chantôme A, Plenchette S, Khochbin S, Solary E, Garrido C (2003). "HSP27 is a ubiquitin-binding protein involved in I-kappaBalpha proteasomal degradation". Mol. Cell. Biol. 23 (16): 5790–802. doi:10.1128/MCB.23.16.5790-5802.2003. PMC 166315. PMID 12897149.