HSD17B11

Estradiol 17-beta-dehydrogenase 11 is an enzyme that in humans is encoded by the HSD17B11 gene.[5][6][7][8]

HSD17B11
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1YB1
Identifiers
Aliases	HSD17B11, 17-BETA-HSD11, 17-BETA-HSDXI, 17BHSD11, DHRS8, PAN1B, RETSDR2, SDR16C2, hydroxysteroid (17-beta) dehydrogenase 11, hydroxysteroid 17-beta dehydrogenase 11
External IDs	OMIM: 612831 MGI: 2149821 HomoloGene: 69209 GeneCards: HSD17B11
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q22.1 Start 87,336,515 bp[1] End 87,391,188 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 E5 Start 103,989,762 bp[2] End 104,021,919 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • oxidoreductase activity • steroid dehydrogenase activity • estradiol 17-beta-dehydrogenase activity Cellular component • cytoplasm • extracellular region • cytosol • lipid droplet Biological process • estrogen biosynthetic process • androgen catabolic process • oxidation-reduction process • lipid metabolism • steroid biosynthetic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51170	114664
Ensembl	ENSG00000198189	ENSMUSG00000029311
UniProt	Q8NBQ5	Q9EQ06
RefSeq (mRNA)	NM_016245	NM_053262
RefSeq (protein)	NP_057329	NP_444492
Location (UCSC)	Chr 4: 87.34 – 87.39 Mb	Chr 5: 103.99 – 104.02 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000198189 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029311 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Brereton P, Suzuki T, Sasano H, Li K, Duarte C, Obeyesekere V, Haeseleer F, Palczewski K, Smith I, Komesaroff P, Krozowski Z (January 2001). "Pan1b (17betaHSD11)-enzymatic activity and distribution in the lung". Molecular and Cellular Endocrinology. 171 (1–2): 111–7. doi:10.1016/S0303-7207(00)00417-2. PMID 11165019.
6. Chai Z, Brereton P, Suzuki T, Sasano H, Obeyesekere V, Escher G, Saffery R, Fuller P, Enriquez C, Krozowski Z (May 2003). "17 beta-hydroxysteroid dehydrogenase type XI localizes to human steroidogenic cells". Endocrinology. 144 (5): 2084–91. doi:10.1210/en.2002-221030. PMID 12697717.
7. Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jörnvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (March 2009). "The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative". Chemico-Biological Interactions. 178 (1–3): 94–8. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.
8. "Entrez Gene: HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11".

Further reading

• Li KX, Smith RE, Krozowski ZS (1999). "Cloning and expression of a novel tissue specific 17beta-hydroxysteroid dehydrogenase". Endocrine Research. 24 (3–4): 663–7. doi:10.3109/07435809809032667. PMID 9888557.
• Haeseleer F, Palczewski K (2000). "Short-chain dehydrogenases/reductases in retina". Methods in Enzymology. 316: 372–83. doi:10.1016/S0076-6879(00)16736-9. PMID 10800688.
• Hartmann TB, Thiel D, Dummer R, Schadendorf D, Eichmüller S (February 2004). "SEREX identification of new tumour-associated antigens in cutaneous T-cell lymphoma". The British Journal of Dermatology. 150 (2): 252–8. doi:10.1111/j.1365-2133.2004.05651.x. PMID 14996095.
• Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.