HS3ST1

Heparan sulfate glucosamine 3-O-sulfotransferase 1 is an enzyme that in humans is encoded by the HS3ST1 gene.[5][6]

HS3ST1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1ZRH
Identifiers
Aliases	HS3ST1, 3OST, 3OST1, heparan sulfate-glucosamine 3-sulfotransferase 1
External IDs	OMIM: 603244 MGI: 1201606 HomoloGene: 3751 GeneCards: HS3ST1
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4p15.33 Start 11,393,150 bp[1] End 11,429,564 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 B3|5 21.14 cM Start 39,613,935 bp[2] End 39,755,475 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • sulfotransferase activity • [heparan sulfate-glucosamine 3-sulfotransferase 1 activity] • heparan sulfate sulfotransferase activity Cellular component • Golgi lumen • integral component of membrane • Golgi apparatus Biological process • glycosaminoglycan biosynthetic process • heparan sulfate proteoglycan biosynthetic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9957	15476
Ensembl	ENSG00000002587	ENSMUSG00000051022
UniProt	O14792	O35310
RefSeq (mRNA)	NM_005114	NM_010474
RefSeq (protein)	NP_005105	NP_034604
Location (UCSC)	Chr 4: 11.39 – 11.43 Mb	Chr 5: 39.61 – 39.76 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It possesses both heparan sulfate glucosaminyl 3-O-sulfotransferase activity, anticoagulant heparan sulfate conversion activity, and is a rate limiting enzyme for synthesis of anticoagulant heparan. This enzyme is an intraluminal Golgi resident protein.[6]

Clinical significance

Polymorphisms in HS3ST1 appear to be a risk factor for developing Alzheimer's disease.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000002587 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000051022 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Shworak NW, Liu J, Petros LM, Zhang L, Kobayashi M, Copeland NG, Jenkins NA, Rosenberg RD (February 1999). "Multiple isoforms of heparan sulfate D-glucosaminyl 3-O-sulfotransferase. Isolation, characterization, and expression of human cdnas and identification of distinct genomic loci". The Journal of Biological Chemistry. 274 (8): 5170–84. doi:10.1074/jbc.274.8.5170. PMID 9988767.
6. "Entrez Gene: HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1".
7. Witoelar A, Rongve A, Almdahl IS, et al. (2018-12-27). "Meta-analysis of Alzheimer's disease on 9,751 samples from Norway and IGAP study identifies four risk loci". Scientific Reports. 8 (1): 18088. doi:10.1038/s41598-018-36429-6. PMC 6308232. PMID 30591712.

Further reading

• Razi N, Lindahl U (May 1995). "Biosynthesis of heparin/heparan sulfate. The D-glucosaminyl 3-O-sulfotransferase reaction: target and inhibitor saccharides". The Journal of Biological Chemistry. 270 (19): 11267–75. doi:10.1074/jbc.270.19.11267. PMID 7744762.
• Liu J, Shworak NW, Fritze LM, Edelberg JM, Rosenberg RD (October 1996). "Purification of heparan sulfate D-glucosaminyl 3-O-sulfotransferase". The Journal of Biological Chemistry. 271 (43): 27072–82. doi:10.1074/jbc.271.43.27072. PMID 8900198.
• Shworak NW, Liu J, Fritze LM, Schwartz JJ, Zhang L, Logeart D, Rosenberg RD (October 1997). "Molecular cloning and expression of mouse and human cDNAs encoding heparan sulfate D-glucosaminyl 3-O-sulfotransferase". The Journal of Biological Chemistry. 272 (44): 28008–19. doi:10.1074/jbc.272.44.28008. PMID 9346953.
• Liu J, Shworak NW, Sinaÿ P, Schwartz JJ, Zhang L, Fritze LM, Rosenberg RD (February 1999). "Expression of heparan sulfate D-glucosaminyl 3-O-sulfotransferase isoforms reveals novel substrate specificities". The Journal of Biological Chemistry. 274 (8): 5185–92. doi:10.1074/jbc.274.8.5185. PMID 9988768.
• Hernaiz M, Liu J, Rosenberg RD, Linhardt RJ (September 2000). "Enzymatic modification of heparan sulfate on a biochip promotes its interaction with antithrombin III". Biochemical and Biophysical Research Communications. 276 (1): 292–7. doi:10.1006/bbrc.2000.3453. PMID 11006120.
• Edavettal SC, Carrick K, Shah RR, Pedersen LC, Tropsha A, Pope RM, Liu J (April 2004). "A conformational change in heparan sulfate 3-O-sulfotransferase-1 is induced by binding to heparan sulfate". Biochemistry. 43 (16): 4680–8. doi:10.1021/bi0499112. PMID 15096036.

External links

• Overview of all the structural information available in the PDB for UniProt: O14792 (Human Heparan sulfate glucosamine 3-O-sulfotransferase 1) at the PDBe-KB.
• Overview of all the structural information available in the PDB for UniProt: O35310 (Mouse Heparan sulfate glucosamine 3-O-sulfotransferase 1) at the PDBe-KB.