HRBL

Arf-GAP domain and FG repeats-containing protein 2 is a protein that in humans is encoded by the AGFG2 gene.[5][6]

AGFG2
Identifiers
AliasesAGFG2, HRBL, RABR, ArfGAP with FG repeats 2
External IDsOMIM: 604019 MGI: 2443267 HomoloGene: 4430 GeneCards: AGFG2
Gene location (Human)
Chr.Chromosome 7 (human)[1]
Band7q22.1Start100,539,203 bp[1]
End100,568,220 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

3268

231801

Ensembl

ENSG00000106351

ENSMUSG00000029722

UniProt

O95081

Q80WC7

RefSeq (mRNA)

NM_006076

NM_145566
NM_178162
NM_001303266
NM_001303271

RefSeq (protein)

NP_006067

NP_001290195
NP_001290200
NP_835456

Location (UCSC)Chr 7: 100.54 – 100.57 MbChr 5: 137.65 – 137.68 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene is a member of the HIV-1 Rev binding protein (HRB) family and encodes a protein with one Arf-GAP zinc finger domain, several phe-gly (FG) motifs, and four asn-pro-phe (NPF) motifs. This protein interacts with Eps15 homology (EH) domains and plays a role in the Rev export pathway, which mediates the nucleocytoplasmic transfer of proteins and RNAs. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000106351 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000029722 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Glockner G, Scherer S, Schattevoy R, Boright A, Weber J, Tsui LC, Rosenthal A (Dec 1998). "Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes". Genome Res. 8 (10): 1060–73. doi:10.1101/gr.8.10.1060. PMC 310788. PMID 9799793.
  6. "Entrez Gene: HRBL HIV-1 Rev binding protein-like".

Further reading


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