Hippocalcin-like protein 4

Hippocalcin like 4, also known as HPCAL4, is a human gene.[5]

HPCAL4
Identifiers
Aliases	HPCAL4, HLP4, hippocalcin like 4
External IDs	MGI: 2157521 HomoloGene: 9441 GeneCards: HPCAL4
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p34.2 Start 39,678,648 bp[1] End 39,691,485 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D2.2 Start 123,183,227 bp[2] End 123,194,701 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • calcium ion binding • calcium channel regulator activity • GO:0001948 protein binding • metal ion binding • protein C-terminus binding • protein domain specific binding Cellular component • intracellular Biological process • central nervous system development • signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51440	170638
Ensembl	ENSG00000116983	ENSMUSG00000046093
UniProt	Q9UM19	Q8BGZ1
RefSeq (mRNA)	NM_016257 NM_001282396 NM_001282397	NM_174998
RefSeq (protein)	NP_001269325 NP_001269326 NP_057341	NP_778163
Location (UCSC)	Chr 1: 39.68 – 39.69 Mb	Chr 4: 123.18 – 123.19 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene is highly similar to human hippocalcin protein and hippocalcin like-1 protein. It also has similarity to rat neural visinin-like Ca2+-binding protein-type 1 and 2 proteins. It is a member of the neuronal calcium sensor family.[6] This encoded protein may be involved in the calcium-dependent regulation of rhodopsin phosphorylation. The transcript of this gene has multiple polyadenylation sites.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000116983 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000046093 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: HPCAL4 hippocalcin like 4".
6. Burgoyne RD (March 2007). "Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling". Nature Reviews. Neuroscience. 8 (3): 182–93. doi:10.1038/nrn2093. PMC 1887812. PMID 17311005.

Further reading

• Kobayashi M, Sakai E, Furuta Y, Takamatsu K (1999). "Isolation of two human cDNAs, HLP3 and HLP4, homologous to the neuron-specific calcium-binding protein genes". DNA Sequence. 9 (3): 171–6. doi:10.3109/10425179809072192. PMID 10520747.
• Hartley JL, Temple GF, Brasch MA (November 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (September 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (October 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (January 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.