HORMAD1

HORMA domain-containing protein 1 (HORMAD1) also known as cancer/testis antigen 46 (CT46) is a protein that in humans is encoded by the HORMAD1 gene.[5][6][7]

HORMAD1
Identifiers
Aliases	HORMAD1, CT46, NOHMA, HORMA domain containing 1
External IDs	OMIM: 609824 MGI: 1915231 HomoloGene: 69415 GeneCards: HORMAD1
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q21.3 Start 150,698,060 bp[1] End 150,720,895 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F2.1 Start 95,559,677 bp[2] End 95,587,671 bp[2]
Orthologs
Species	Human	Mouse
Entrez	84072	67981
Ensembl	ENSG00000143452	ENSMUSG00000028109
UniProt	Q86X24	Q9D5T7
RefSeq (mRNA)	NM_001199829 NM_032132	NM_001289532 NM_001289534 NM_001289537 NM_026489 NM_001373886
RefSeq (protein)	NP_001186758 NP_115508	NP_001276461 NP_001276463 NP_001276466 NP_080765 NP_001360815
Location (UCSC)	Chr 1: 150.7 – 150.72 Mb	Chr 3: 95.56 – 95.59 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

HORMAD1 plays a key role in meiotic progression. Regulates 3 different functions during meiosis. It:

1. ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single-stranded DSB ends.
2. promotes synaptonemal-complex formation independently of its role in homology search.
3. plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes (By similarity)

References

1. GRCh38: Ensembl release 89: ENSG00000143452 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028109 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
6. Chen YT, Venditti CA, Theiler G, Stevenson BJ, Iseli C, Gure AO, Jongeneel CV, Old LJ, Simpson AJ (Jul 2005). "Identification of CT46/HORMAD1, an immunogenic cancer/testis antigen encoding a putative meiosis-related protein". Cancer Immun. 5: 9. PMID 15999985.
7. "Entrez Gene: HORMAD1 HORMA domain containing 1".

Further reading

• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Pangas SA, Yan W, Matzuk MM, Rajkovic A (2006). "Restricted germ cell expression of a gene encoding a novel mammalian HORMA domain-containing protein". Gene Expr. Patterns. 5 (2): 257–63. doi:10.1016/j.modgep.2004.07.008. PMID 15567723.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.