HNRPH3

Heterogeneous nuclear ribonucleoprotein H3 is a protein that in humans is encoded by the HNRNPH3 gene.[5][6]

HNRNPH3
Identifiers
Aliases	HNRNPH3, 2H9, HNRPH3, heterogeneous nuclear ribonucleoprotein H3
External IDs	OMIM: 602324 MGI: 1926462 HomoloGene: 11012 GeneCards: HNRNPH3
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q21.3 Start 68,331,174 bp[1] End 68,343,191 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 B4 Start 63,014,664 bp[2] End 63,024,217 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • nucleic acid binding • RNA binding Cellular component • spliceosomal complex • cell nucleus • nucleoplasm Biological process • mRNA splicing, via spliceosome • mRNA processing • RNA processing • epithelial cell differentiation • RNA splicing Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3189	432467
Ensembl	ENSG00000096746	ENSMUSG00000020069
UniProt	P31942	n/a
RefSeq (mRNA)	NM_012207 NM_021644 NM_001322434 NM_001322436 NM_001322437 NM_001322438 NM_001322439 NM_001322440 NM_001322441 NM_001322442 NM_001322443 NM_001322444 NM_001322445 NM_001322446 NM_001322447 NM_001322448 NM_001322449 NM_001322450 NM_001322451 NM_001322452 NM_001322453	NM_001079824 NM_001347457 NM_001359260 NM_001359261
RefSeq (protein)	NP_001309363 NP_001309365 NP_001309366 NP_001309367 NP_001309368 NP_001309369 NP_001309370 NP_001309371 NP_001309372 NP_001309373 NP_001309374 NP_001309375 NP_001309376 NP_001309377 NP_001309378 NP_001309379 NP_001309380 NP_001309381 NP_001309382 NP_036339 NP_067676	n/a
Location (UCSC)	Chr 10: 68.33 – 68.34 Mb	Chr 10: 63.01 – 63.02 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It is localized in nuclear bodies of the nucleus. This protein is involved in the splicing process and it also participates in early heat shock-induced splicing arrest by transiently leaving the hnRNP complexes. Multiple alternative transcript variants seem to be present for this gene and some appear to have intronic regions in the mRNA. Presently, only two transcript variants are fully described.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000096746 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020069 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Mahe D, Mahl P, Gattoni R, Fischer N, Mattei MG, Stevenin J, Fuchs JP (Feb 1997). "Cloning of human 2H9 heterogeneous nuclear ribonucleoproteins. Relation with splicing and early heat shock-induced splicing arrest". J Biol Chem. 272 (3): 1827–36. doi:10.1074/jbc.272.3.1827. PMID 8999868.
6. "Entrez Gene: HNRPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9)".

Further reading

• Rasmussen HH, van Damme J, Puype M, et al. (1993). "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes". Electrophoresis. 13 (12): 960–9. doi:10.1002/elps.11501301199. PMID 1286667.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Honoré B (2000). "The hnRNP 2H9 gene, which is involved in the splicing reaction, is a multiply spliced gene". Biochim. Biophys. Acta. 1492 (1): 108–19. doi:10.1016/s0167-4781(00)00092-0. PMID 10858537.
• Mahé D, Fischer N, Décimo D, Fuchs JP (2000). "Spatiotemporal regulation of hnRNP M and 2H9 gene expression during mouse embryonic development". Biochim. Biophys. Acta. 1492 (2–3): 414–24. doi:10.1016/s0167-4781(00)00144-5. PMID 11004512.
• Yagüe J, Vázquez J, López de Castro JA (2001). "A post-translational modification of nuclear proteins, N(G),N(G)-dimethyl-Arg, found in a natural HLA class I peptide ligand". Protein Sci. 9 (11): 2210–7. doi:10.1110/ps.9.11.2210. PMC 2144492. PMID 11152131.
• Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.