HM13

Minor histocompatibility antigen H13 is a protein that in humans is encoded by the HM13 gene.[5][6][7]

HM13
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1INQ, 1JUF
Identifiers
Aliases	HM13, H13, IMP1, IMPAS, IMPAS-1, MSTP086, PSENL3, PSL3, SPP, SPPL1, dJ324O17.1, histocompatibility (minor) 13, histocompatibility minor 13
External IDs	OMIM: 607106 MGI: 95886 HomoloGene: 7749 GeneCards: HM13
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q11.21 Start 31,514,410 bp[1] End 31,577,923 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 H1|2 75.41 cM Start 152,669,461 bp[2] End 152,708,670 bp[2]
Gene ontology Molecular function • protein homodimerization activity • aspartic-type endopeptidase activity • aspartic endopeptidase activity, intramembrane cleaving • peptidase activity • GO:0001948 protein binding • hydrolase activity • ubiquitin protein ligase binding Cellular component • integral component of membrane • rough endoplasmic reticulum • endoplasmic reticulum membrane • membrane • integral component of cytoplasmic side of endoplasmic reticulum membrane • cell membrane • Derlin-1 retrotranslocation complex • integral component of lumenal side of endoplasmic reticulum membrane • Golgi-associated vesicle membrane • lysosomal membrane • endoplasmic reticulum • cell surface Biological process • membrane protein proteolysis • proteolysis • membrane protein proteolysis involved in retrograde protein transport, ER to cytosol • membrane protein intracellular domain proteolysis • membrane protein ectodomain proteolysis • protein homotetramerization • signal peptide processing Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	81502	14950
Ensembl	ENSG00000101294	ENSMUSG00000019188
UniProt	Q8TCT9	Q9D8V0
RefSeq (mRNA)	NM_030789 NM_178580 NM_178581 NM_178582	NM_001159551 NM_001159552 NM_001159553 NM_010376
RefSeq (protein)	NP_110416 NP_848695 NP_848696 NP_848697	NP_001153023 NP_001153024 NP_001153025 NP_034506
Location (UCSC)	Chr 20: 31.51 – 31.58 Mb	Chr 2: 152.67 – 152.71 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The minor histocompatibility antigen 13 is a nonamer peptide that originates from a protein encoded by the H13 gene.[8][9] The peptide is generated by the cytosol by the proteasome, enters the endoplasmic reticulum (ER) lumen by the transporter associated with antigen processing (TAP) and is presented on the cell surface on H2-D^b major histocompatibility antigen I (MHC I) molecules. The alloreactivity, which leads to transplant rejection in mice, is conferred by Val/Ile polymorphism in the ‘SSV(V/I)GVWYL’ peptide.[10] The orthologue gene in humans is called HM13. If a related polymorphism exists, and if the HM13 serves as a Minor histocompatibility antigen, however, remains to be addressed.

The protein encoded by the M13/HM13 gene is the signal peptide peptidase (SPP), an ER-resident intramembrane protease.[5] SPP localizes to the endoplasmic reticulum, catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein. This activity is required to generate signal sequence-derived human lymphocyte antigen-E epitopes that are recognized by the immune system, and to process hepatitis C virus core protein. The encoded protein is an integral membrane protein with sequence motifs characteristic of the presenilin-type aspartic proteases. Multiple transcript variants encoding several different isoforms have been found for this gene.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000101294 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000019188 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Weihofen A, Binns K, Lemberg MK, Ashman K, Martoglio B (Jun 2002). "Identification of signal peptide peptidase, a presenilin-type aspartic protease". Science. 296 (5576): 2215–8. doi:10.1126/science.1070925. PMID 12077416.
6. Nyborg AC, Kornilova AY, Jansen K, Ladd TB, Wolfe MS, Golde TE (Apr 2004). "Signal peptide peptidase forms a homodimer that is labeled by an active site-directed gamma-secretase inhibitor". J Biol Chem. 279 (15): 15153–60. doi:10.1074/jbc.M309305200. PMID 14704149.
7. "Entrez Gene: HM13 histocompatibility (minor) 13".
8. "Entrez Gene: H13 histocompatibility (minor) 13".
9. Snell GD, Cudkowicz G, Bunker HP (Jun 1967). "Histocompatibility genes of mice. VII. H-13, a new histocompatibility locus in the fifth linkage group". Transplantation. 5 (3): 492–503. doi:10.1097/00007890-196705000-00011. PMID 5340356.
10. Mendoza LM, Paz P, Zuberi A, Christianson G, Roopenian D, Shastri N (Oct 1997). "Minors held by majors: the H13 minor histocompatibility locus defined as a peptide/MHC class I complex". Immunity. 7 (4): 461–72. doi:10.1016/S1074-7613(00)80368-4. PMID 9354467.

Further reading

• Lemberg MK, Bland FA, Weihofen A, et al. (2002). "Intramembrane proteolysis of signal peptides: an essential step in the generation of HLA-E epitopes". J. Immunol. 167 (11): 6441–6. doi:10.4049/jimmunol.167.11.6441. PMID 11714810.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
• Grigorenko AP, Moliaka YK, Korovaitseva GI, Rogaev EI (2002). "Novel class of polytopic proteins with domains associated with putative protease activity". Biochemistry Mosc. 67 (7): 826–35. doi:10.1023/A:1016365227942. PMID 12139484.
• McLauchlan J, Lemberg MK, Hope G, Martoglio B (2002). "Intramembrane proteolysis promotes trafficking of hepatitis C virus core protein to lipid droplets". EMBO J. 21 (15): 3980–8. doi:10.1093/emboj/cdf414. PMC 126158. PMID 12145199.
• Lemberg MK, Martoglio B (2002). "Requirements for signal peptide peptidase-catalyzed intramembrane proteolysis". Mol. Cell. 10 (4): 735–44. doi:10.1016/S1097-2765(02)00655-X. PMID 12419218.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Urny J, Hermans-Borgmeyer I, Gercken G, Schaller HC (2004). "Expression of the presenilin-like signal peptide peptidase (SPP) in mouse adult brain and during development". Gene Expr. Patterns. 3 (5): 685–91. doi:10.1016/S1567-133X(03)00094-2. PMID 12972007.
• Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Moliaka YK, Grigorenko A, Madera D, Rogaev EI (2004). "Impas 1 possesses endoproteolytic activity against multipass membrane protein substrate cleaving the presenilin 1 holoprotein". FEBS Lett. 557 (1–3): 185–92. doi:10.1016/S0014-5793(03)01489-3. PMID 14741365.
• Soares MR, Bisch PM, Campos de Carvalho AC, et al. (2004). "Correlation between conformation and antibody binding: NMR structure of cross-reactive peptides from T. cruzi, human and L. braziliensis". FEBS Lett. 560 (1–3): 134–40. doi:10.1016/S0014-5793(04)00088-2. PMID 14988012.
• Friedmann E, Lemberg MK, Weihofen A, et al. (2005). "Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins". J. Biol. Chem. 279 (49): 50790–8. doi:10.1074/jbc.M407898200. PMID 15385547.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Urny J, Hermans-Borgmeyer I, Schaller HC (2006). "Cell-surface expression of a new splice variant of the mouse signal peptide peptidase". Biochim. Biophys. Acta. 1759 (3–4): 159–65. doi:10.1016/j.bbaexp.2006.02.007. PMID 16730383.
• Loureiro J, Lilley BN, Spooner E, et al. (2006). "Signal peptide peptidase is required for dislocation from the endoplasmic reticulum". Nature. 441 (7095): 894–7. doi:10.1038/nature04830. PMID 16738546.
• Sato T, Nyborg AC, Iwata N, et al. (2006). "Signal peptide peptidase: biochemical properties and modulation by nonsteroidal antiinflammatory drugs". Biochemistry. 45 (28): 8649–56. doi:10.1021/bi060597g. PMID 16834339.