HIST1H2BI

Histone H2B type 1-C/E/F/G/I is a protein that in humans is encoded by the HIST1H2BI gene.[4][5][6]

H2BC10
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5KGF
Identifiers
Aliases	H2BC10, H2B/k, H2BFK, histone cluster 1, H2bi, histone cluster 1 H2B family member i, H2B clustered histone 10, HIST1H2BI, H2BC8, H2BC7, H2BC6, H2BC4
External IDs	OMIM: 602807 MGI: 1915274 HomoloGene: 135944 GeneCards: H2BC10
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p22.2 Start 26,272,976 bp[1] End 26,273,356 bp[1]
Gene ontology Molecular function • DNA binding • GO:0001948 protein binding • protein heterodimerization activity • identical protein binding Cellular component • chromosome • nucleosome • extracellular exosome • cell nucleus • nucleoplasm • extracellular • cytosol Biological process • nucleosome assembly • innate immune response in mucosa • defense response to bacterium • protein ubiquitination • antimicrobial humoral immune response mediated by antimicrobial peptide Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8346	68024
Ensembl	ENSG00000278588	n/a
UniProt	P62807	Q6ZWY9
RefSeq (mRNA)	NM_003525	NM_001290380 NM_023422
RefSeq (protein)	NP_003517 NP_001368918	NP_835503 NP_001171124 NP_001277459 NP_835501 NP_001277309 NP_075911
Location (UCSC)	Chr 6: 26.27 – 26.27 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000278588 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Albig W, Kioschis P, Poustka A, Meergans K, Doenecke D (Apr 1997). "Human histone gene organization: nonregular arrangement within a large cluster". Genomics. 40 (2): 314–22. doi:10.1006/geno.1996.4592. PMID 9119399.
5. Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
6. "Entrez Gene: HIST1H2BI histone cluster 1, H2bi".

Further reading

• Lusic M, Marcello A, Cereseto A, Giacca M (2004). "Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter". EMBO J. 22 (24): 6550–61. doi:10.1093/emboj/cdg631. PMC 291826. PMID 14657027.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Deng L, Wang D, de la Fuente C, et al. (2001). "Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA". Virology. 289 (2): 312–26. doi:10.1006/viro.2001.1129. PMID 11689053.
• Deng L, de la Fuente C, Fu P, et al. (2001). "Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones". Virology. 277 (2): 278–95. doi:10.1006/viro.2000.0593. PMID 11080476.
• El Kharroubi A, Piras G, Zensen R, Martin MA (1998). "Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter". Mol. Cell. Biol. 18 (5): 2535–44. doi:10.1128/mcb.18.5.2535. PMC 110633. PMID 9566873.
• Albig W, Doenecke D (1998). "The human histone gene cluster at the D6S105 locus". Hum. Genet. 101 (3): 284–94. doi:10.1007/s004390050630. PMID 9439656.