HIST1H2BD

Histone H2B type 1-D is a protein that in humans is encoded by the HIST1H2BD gene.[4][5][6]

H2BC5
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesH2BC5, H2B.1B, H2B/b, H2BFB, HIRIP2, dJ221C16.6, histone cluster 1, H2bd, histone cluster 1 H2B family member d, H2BFG, H2BFL, H2B/k, H2B/l, H2B/h, H2BFK, HIST1H2BE, HIST1H2BC, HIST1H2BG, HIST1H2BI, H2BFA, H2BFH, H2B/a, H2B/g, HIST1H2BF, HIST1H2BD, H2B clustered histone 5
External IDsOMIM: 602799 MGI: 1925553 HomoloGene: 134740 GeneCards: H2BC5
Gene location (Human)
Chr.Chromosome 6 (human)[1]
Band6p22.2Start26,158,146 bp[1]
End26,171,349 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

3017

78303

Ensembl

ENSG00000158373

n/a

UniProt

P58876
P62807

Q9D2U9

RefSeq (mRNA)

NM_021063
NM_138720

NM_030082

RefSeq (protein)

NP_066407
NP_619790
NP_003517
NP_001368918

NP_084358

Location (UCSC)Chr 6: 26.16 – 26.17 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryote. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2B family. Two transcripts that encode the same protein have been identified for this gene, which is found in the large histone gene cluster on chromosome 6p22-p21.3.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000158373 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Albig W, Kardalinou E, Drabent B, Zimmer A, Doenecke D (Nov 1991). "Isolation and characterization of two human H1 histone genes within clusters of core histone genes". Genomics. 10 (4): 940–8. doi:10.1016/0888-7543(91)90183-F. PMID 1916825.
  5. Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
  6. "Entrez Gene: HIST1H2BD histone cluster 1, H2bd".

Further reading


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