HIST1H2AI

Histone H2A type 1 is a protein that in humans is encoded by the HIST1H2AI gene.[3][4][5]

H2AC13
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesH2AC13, H2A/c, H2AFC, histone cluster 1, H2ai, histone cluster 1 H2A family member i, H2A clustered histone 13, HIST1H2AI, H2AC11, H2AC15, H2AC17, H2AC16
External IDsOMIM: 602787 HomoloGene: 134476 GeneCards: H2AC13
Gene location (Human)
Chr.Chromosome 6 (human)[1]
Band6p22.1Start27,808,199 bp[1]
End27,808,701 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

8329

n/a

Ensembl

ENSG00000196747

n/a

UniProt

P0C0S8

n/a

RefSeq (mRNA)

NM_003509

n/a

RefSeq (protein)

NP_066408
NP_003505

n/a

Location (UCSC)Chr 6: 27.81 – 27.81 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3.[5]

References

  1. GRCh38: Ensembl release 89: ENSG00000196747 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. Albig W, Doenecke D (Feb 1998). "The human histone gene cluster at the D6S105 locus". Hum Genet. 101 (3): 284–94. doi:10.1007/s004390050630. PMID 9439656.
  4. Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
  5. "Entrez Gene: HIST1H2AI histone cluster 1, H2ai".

Further reading

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