HIST1H2AI

Histone H2A type 1 is a protein that in humans is encoded by the HIST1H2AI gene.[3][4][5]

H2AC13
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 4QYL, 5KGF
Identifiers
Aliases	H2AC13, H2A/c, H2AFC, histone cluster 1, H2ai, histone cluster 1 H2A family member i, H2A clustered histone 13, HIST1H2AI, H2AC11, H2AC15, H2AC17, H2AC16
External IDs	OMIM: 602787 HomoloGene: 134476 GeneCards: H2AC13
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p22.1 Start 27,808,199 bp[1] End 27,808,701 bp[1]
Gene ontology Molecular function • enzyme binding • DNA binding • GO:0001948 protein binding • protein heterodimerization activity Cellular component • nuclear chromatin • nucleosome • extracellular exosome • cell nucleus • chromosome Biological process • chromatin silencing • chromatin organization • biological process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8329	n/a
Ensembl	ENSG00000196747	n/a
UniProt	P0C0S8	n/a
RefSeq (mRNA)	NM_003509	n/a
RefSeq (protein)	NP_066408 NP_003505	n/a
Location (UCSC)	Chr 6: 27.81 – 27.81 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000196747 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Albig W, Doenecke D (Feb 1998). "The human histone gene cluster at the D6S105 locus". Hum Genet. 101 (3): 284–94. doi:10.1007/s004390050630. PMID 9439656.
4. Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
5. "Entrez Gene: HIST1H2AI histone cluster 1, H2ai".

Further reading

• Lusic M, Marcello A, Cereseto A, Giacca M (2004). "Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter". EMBO J. 22 (24): 6550–61. doi:10.1093/emboj/cdg631. PMC 291826. PMID 14657027.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Deng L, Wang D, de la Fuente C, et al. (2001). "Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA". Virology. 289 (2): 312–26. doi:10.1006/viro.2001.1129. PMID 11689053.
• Deng L, de la Fuente C, Fu P, et al. (2001). "Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones". Virology. 277 (2): 278–95. doi:10.1006/viro.2000.0593. PMID 11080476.
• Albig W, Trappe R, Kardalinou E, et al. (1999). "The human H2A and H2B histone gene complement". Biol. Chem. 380 (1): 7–18. doi:10.1515/BC.1999.002. PMID 10064132.
• El Kharroubi A, Piras G, Zensen R, Martin MA (1998). "Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter". Mol. Cell. Biol. 18 (5): 2535–44. doi:10.1128/mcb.18.5.2535. PMC 110633. PMID 9566873.