HIST1H2AB

Histone H2A type 1-B/E is a protein that in humans is encoded by the HIST1H2AB gene.[5][6][7][8]

H2AC4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesH2AC4, H2A/m, H2AFM, histone cluster 1, H2ab, histone cluster 1 H2A family member b, HIST1H2AB, H2A clustered histone 4, H2AC8
External IDsOMIM: 602795 MGI: 2448293 HomoloGene: 135982 GeneCards: H2AC4
Gene location (Human)
Chr.Chromosome 6 (human)[1]
Band6p22.2Start26,033,176 bp[1]
End26,033,568 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

8335

319167

Ensembl

ENSG00000278463

ENSMUSG00000069301

UniProt

P04908

RefSeq (mRNA)

NM_003513

NM_178186

RefSeq (protein)

NP_003504

Location (UCSC)Chr 6: 26.03 – 26.03 MbChr 13: 22.04 – 22.04 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000278463 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000069301 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Albig W, Doenecke D (Feb 1998). "The human histone gene cluster at the D6S105 locus". Hum Genet. 101 (3): 284–94. doi:10.1007/s004390050630. PMID 9439656.
  6. Albig W, Kioschis P, Poustka A, Meergans K, Doenecke D (Apr 1997). "Human histone gene organization: nonregular arrangement within a large cluster". Genomics. 40 (2): 314–22. doi:10.1006/geno.1996.4592. PMID 9119399.
  7. Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
  8. "Entrez Gene: HIST1H2AB histone cluster 1, H2ab".

Further reading


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.