HIPK3

Homeodomain-interacting protein kinase 3 is an enzyme that in humans is encoded by the HIPK3 gene.[5][6][7]

HIPK3
Identifiers
Aliases	HIPK3, DYRK6, FIST3, PKY, YAK1, homeodomain interacting protein kinase 3
External IDs	OMIM: 604424 MGI: 1314882 HomoloGene: 55923 GeneCards: HIPK3
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p13 Start 33,256,672 bp[1] End 33,357,023 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 E2 Start 104,426,481 bp[2] End 104,494,446 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • kinase activity • transferase activity • protein kinase activity • nucleotide binding • protein serine/threonine kinase activity • ATP binding Cellular component • PML body • cell nucleus • cytoplasm • cytosol • nuclear body Biological process • protein phosphorylation • mRNA transcription • peptidyl-threonine phosphorylation • regulation of transcription, DNA-templated • negative regulation of apoptotic process • negative regulation of JUN kinase activity • peptidyl-serine phosphorylation • transcription, DNA-templated • phosphorylation • apoptotic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10114	15259
Ensembl	ENSG00000110422	ENSMUSG00000027177
UniProt	Q9H422	Q9ERH7
RefSeq (mRNA)	NM_001048200 NM_001278162 NM_001278163 NM_005734	NM_001145824 NM_010434
RefSeq (protein)	NP_001041665 NP_001265091 NP_001265092 NP_005725	NP_001139296 NP_034564
Location (UCSC)	Chr 11: 33.26 – 33.36 Mb	Chr 2: 104.43 – 104.49 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000110422 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027177 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Begley DA, Berkenpas MB, Sampson KE, Abraham I (Dec 1997). "Identification and sequence of human PKY, a putative kinase with increased expression in multidrug-resistant cells, with homology to yeast protein kinase Yak1". Gene. 200 (1–2): 35–43. doi:10.1016/S0378-1119(97)00350-8. PMID 9373137.
6. Kim YH, Choi CY, Lee SJ, Conti MA, Kim Y (Nov 1998). "Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors". J Biol Chem. 273 (40): 25875–9. doi:10.1074/jbc.273.40.25875. PMID 9748262.
7. "Entrez Gene: HIPK3 homeodomain interacting protein kinase 3".

Further reading

• Moilanen AM, Karvonen U, Poukka H, et al. (1999). "Activation of Androgen Receptor Function by a Novel Nuclear Protein Kinase". Mol. Biol. Cell. 9 (9): 2527–43. doi:10.1091/mbc.9.9.2527. PMC 25523. PMID 9725910.
• Scaffidi C, Volkland J, Blomberg I, et al. (2000). "Phosphorylation of FADD/ MORT1 at serine 194 and association with a 70-kDa cell cycle-regulated protein kinase". J. Immunol. 164 (3): 1236–42. doi:10.4049/jimmunol.164.3.1236. PMID 10640736.
• Nupponen NN, Visakorpi T (2000). "Assignment of the protein kinase homolog of YAK1 (HIPK3) to human chromosome band 11p13 by in situ hybridization". Cytogenet. Cell Genet. 87 (1–2): 102–3. doi:10.1159/000015404. PMID 10640824.
• Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
• Minty A, Dumont X, Kaghad M, Caput D (2000). "Covalent modification of p73alpha by SUMO-1. Two-hybrid screening with p73 identifies novel SUMO-1-interacting proteins and a SUMO-1 interaction motif". J. Biol. Chem. 275 (46): 36316–23. doi:10.1074/jbc.M004293200. PMID 10961991.
• Rochat-Steiner V, Becker K, Micheau O, et al. (2000). "Fist/Hipk3: A FAS/Fadd-Interacting Serine/Threonine Kinase That Induces Fadd Phosphorylation and Inhibits FAS-Mediated Jun Nh2-Terminal Kinase Activation". J. Exp. Med. 192 (8): 1165–74. doi:10.1084/jem.192.8.1165. PMC 2311455. PMID 11034606.
• Curtin JF, Cotter TG (2004). "JNK regulates HIPK3 expression and promotes resistance to Fas-mediated apoptosis in DU 145 prostate carcinoma cells". J. Biol. Chem. 279 (17): 17090–100. doi:10.1074/jbc.M307629200. PMID 14766760.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
• Venables JP, Bourgeois CF, Dalgliesh C, et al. (2005). "Up-regulation of the ubiquitous alternative splicing factor Tra2beta causes inclusion of a germ cell-specific exon". Hum. Mol. Genet. 14 (16): 2289–303. doi:10.1093/hmg/ddi233. PMID 16000324.
• Taylor TD, Noguchi H, Totoki Y, et al. (2006). "Human chromosome 11 DNA sequence and analysis including novel gene identification". Nature. 440 (7083): 497–500. doi:10.1038/nature04632. PMID 16554811.
• Lan HC, Li HJ, Lin G, et al. (2007). "Cyclic AMP Stimulates SF-1-Dependent CYP11A1 Expression through Homeodomain-Interacting Protein Kinase 3-Mediated Jun N-Terminal Kinase and c-Jun Phosphorylation". Mol. Cell. Biol. 27 (6): 2027–36. doi:10.1128/MCB.02253-06. PMC 1820514. PMID 17210646.

External links

• HIPK3 human gene location in the UCSC Genome Browser.
• HIPK3 human gene details in the UCSC Genome Browser.