HES3

Hes family bHLH transcription factor 3 is a protein that in humans is encoded by the HES3 gene.[5]

HES3
Identifiers
Aliases	HES3, bHLHb43, hes family bHLH transcription factor 3
External IDs	OMIM: 609971 MGI: 104877 HomoloGene: 7358 GeneCards: HES3
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.31 Start 6,244,179 bp[1] End 6,245,578 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 E2|4 83.01 cM Start 152,285,972 bp[2] End 152,291,662 bp[2]
Gene ontology Molecular function • DNA binding • transcription factor binding • protein dimerization activity • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • RNA polymerase II regulatory region sequence-specific DNA binding • GO:0001106 transcription corepressor activity • sequence-specific DNA binding • sequence-specific double-stranded DNA binding Cellular component • cell nucleus Biological process • hindbrain morphogenesis • trochlear nerve development • midbrain-hindbrain boundary morphogenesis • negative regulation of transcription, DNA-templated • in utero embryonic development • negative regulation of transcription from RNA polymerase II promoter • regulation of transcription, DNA-templated • regulation of timing of neuron differentiation • regulation of neurogenesis • oculomotor nerve development • transcription, DNA-templated • midbrain development • positive regulation of transcription from RNA polymerase II promoter • neural tube development • somitogenesis • Notch signaling pathway • cell differentiation • anterior/posterior pattern specification Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	390992	15207
Ensembl	ENSG00000173673	ENSMUSG00000028946
UniProt	Q5TGS1	Q61657
RefSeq (mRNA)	NM_001024598	NM_008237
RefSeq (protein)	NP_001019769	NP_032263
Location (UCSC)	Chr 1: 6.24 – 6.25 Mb	Chr 4: 152.29 – 152.29 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000173673 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028946 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Hes family bHLH transcription factor 3".

Further reading

• Katoh M, Katoh M (August 2004). "Identification and characterization of human HES2, HES3, and HES5 genes in silico". International Journal of Oncology. 25 (2): 529–34. doi:10.3892/ijo.25.2.529. PMID 15254753.
• Katoh M, Katoh M (August 2007). "Integrative genomic analyses on HES/HEY family: Notch-independent HES1, HES3 transcription in undifferentiated ES cells, and Notch-dependent HES1, HES5, HEY1, HEY2, HEYL transcription in fetal tissues, adult tissues, or cancer". International Journal of Oncology. 31 (2): 461–6. doi:10.3892/ijo.31.2.461. PMID 17611704.
• Fukami M, Wada Y, Okada M, Kato F, Katsumata N, Baba T, Morohashi K, Laporte J, Kitagawa M, Ogata T (February 2008). "Mastermind-like domain-containing 1 (MAMLD1 or CXorf6) transactivates the Hes3 promoter, augments testosterone production, and contains the SF1 target sequence". The Journal of Biological Chemistry. 283 (9): 5525–32. doi:10.1074/jbc.M703289200. PMID 18162467.
• Park DM, Jung J, Masjkur J, Makrogkikas S, Ebermann D, Saha S, Rogliano R, Paolillo N, Pacioni S, McKay RD, Poser S, Androutsellis-Theotokis A (2013). "Hes3 regulates cell number in cultures from glioblastoma multiforme with stem cell characteristics". Scientific Reports. 3: 1095. doi:10.1038/srep01095. PMC 3566603. PMID 23393614.