Hes family bhlh transcription factor 2

Hes family bHLH transcription factor 2 is a protein that in humans is encoded by the HES2 gene.[5]

HES2
Identifiers
Aliases	HES2, bHLHb40, hes family bHLH transcription factor 2
External IDs	OMIM: 609970 MGI: 1098624 HomoloGene: 22455 GeneCards: HES2
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.31 Start 6,412,418 bp[1] End 6,424,670 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 E2|4 82.92 cM Start 152,158,867 bp[2] End 152,162,469 bp[2]
Gene ontology Molecular function • DNA binding • double-stranded DNA binding • transcription factor binding • protein dimerization activity • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • RNA polymerase II regulatory region sequence-specific DNA binding • GO:0001106 transcription corepressor activity • sequence-specific DNA binding • sequence-specific double-stranded DNA binding Cellular component • cell nucleus Biological process • negative regulation of transcription, DNA-templated • regulation of transcription, DNA-templated • transcription, DNA-templated • negative regulation of transcription from RNA polymerase II promoter • somitogenesis • Notch signaling pathway • cell differentiation • regulation of neurogenesis • anterior/posterior pattern specification Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	54626	15206
Ensembl	ENSG00000069812	ENSMUSG00000028940
UniProt	Q9Y543	O54792
RefSeq (mRNA)	NM_019089	NM_001301805 NM_008236
RefSeq (protein)	NP_061962	NP_001288734 NP_032262
Location (UCSC)	Chr 1: 6.41 – 6.42 Mb	Chr 4: 152.16 – 152.16 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000069812 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028940 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Hes family bHLH transcription factor 2".

Further reading

• Nishimura M, Isaka F, Ishibashi M, Tomita K, Tsuda H, Nakanishi S, Kageyama R (April 1998). "Structure, chromosomal locus, and promoter of mouse Hes2 gene, a homologue of Drosophila hairy and Enhancer of split". Genomics. 49 (1): 69–75. doi:10.1006/geno.1998.5213. PMID 9570950.
• Katoh M, Katoh M (August 2004). "Identification and characterization of human HES2, HES3, and HES5 genes in silico". International Journal of Oncology. 25 (2): 529–34. doi:10.3892/ijo.25.2.529. PMID 15254753.
• Katoh M, Katoh M (August 2007). "Integrative genomic analyses on HES/HEY family: Notch-independent HES1, HES3 transcription in undifferentiated ES cells, and Notch-dependent HES1, HES5, HEY1, HEY2, HEYL transcription in fetal tissues, adult tissues, or cancer". International Journal of Oncology. 31 (2): 461–6. doi:10.3892/ijo.31.2.461. PMID 17611704.