H2AFY2

Core histone macro-H2A.2 is a protein that in humans is encoded by the H2AFY2 gene.[5][6][7]

MACROH2A2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2XD7
Identifiers
Aliases	MACROH2A2, macroH2A2, H2A histone family member Y2, H2AFY2, macroH2A.2 histone
External IDs	OMIM: 616141 MGI: 3037658 HomoloGene: 10246 GeneCards: MACROH2A2
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q22.1 Start 70,052,846 bp[1] End 70,112,282 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 B4 Start 61,738,665 bp[2] End 61,784,147 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • RNA polymerase II regulatory region sequence-specific DNA binding • protein heterodimerization activity • chromatin DNA binding Cellular component • ESC/E(Z) complex • nucleoplasm • chromosome • nuclear chromatin • nucleosome • chromatin • extracellular exosome • Barr body • nuclear chromosome, telomeric region • cell nucleus Biological process • nucleosome assembly • chromatin silencing • negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter • positive regulation of keratinocyte differentiation • dosage compensation • negative regulation of transcription from RNA polymerase II promoter • establishment of protein localization to chromatin • brain development • negative regulation of gene expression, epigenetic • regulation of cell growth • covalent chromatin modification • chromatin organization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55506	404634
Ensembl	ENSG00000099284	ENSMUSG00000020086
UniProt	Q9P0M6	Q8CCK0
RefSeq (mRNA)	NM_018649	NM_207000
RefSeq (protein)	NP_061119	NP_996883
Location (UCSC)	Chr 10: 70.05 – 70.11 Mb	Chr 10: 61.74 – 61.78 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000099284 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020086 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Chadwick BP, Willard HF (May 2001). "Histone H2A variants and the inactive X chromosome: identification of a second macroH2A variant". Hum Mol Genet. 10 (10): 1101–13. doi:10.1093/hmg/10.10.1101. PMID 11331621.
6. Costanzi C, Pehrson JR (Jun 2001). "MACROH2A2, a new member of the MARCOH2A core histone family". J Biol Chem. 276 (24): 21776–84. doi:10.1074/jbc.M010919200. PMID 11262398.
7. "Entrez Gene: H2AFY2 H2A histone family, member Y2".

Further reading

• El Kharroubi A, Piras G, Zensen R, Martin MA (1998). "Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter". Mol. Cell. Biol. 18 (5): 2535–44. doi:10.1128/mcb.18.5.2535. PMC 110633. PMID 9566873.
• Deng L, de la Fuente C, Fu P, et al. (2001). "Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones". Virology. 277 (2): 278–95. doi:10.1006/viro.2000.0593. PMID 11080476.
• Deng L, Wang D, de la Fuente C, et al. (2001). "Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA". Virology. 289 (2): 312–26. doi:10.1006/viro.2001.1129. PMID 11689053.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Lusic M, Marcello A, Cereseto A, Giacca M (2004). "Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter". EMBO J. 22 (24): 6550–61. doi:10.1093/emboj/cdg631. PMC 291826. PMID 14657027.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Zhang R, Poustovoitov MV, Ye X, et al. (2005). "Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA". Dev. Cell. 8 (1): 19–30. doi:10.1016/j.devcel.2004.10.019. PMID 15621527.