Guadinomine

Guadinomines are anti-infective compounds produced by Streptomyces sp. K01-0509.[1] Guadinomine B is the most potent known inhibitor of the Type III secretion system (TTSS) of Gram-negative bacteria. The guadinomine (gdn) biosynthetic gene cluster includes 26 open reading frames spanning 51.2 kb. Streptomyces sp. K01-0509 produces several derivatives named guadinomines A, B, C1, C2, D, and guadinomic acid.[2]

chemical structure of guadinomine B

References
  1. Iwatsuki, Masato; Uchida, Ryuji; Yoshijima, Hitomi; Ui, Hideaki; Shiomi, Kazuro; Matsumoto, Atsuko; Takahashi, Yoko; Abe, Akio; Tomoda, Hiroshi; Ōmura, Satoshi (2008). "Guadinomines, Type III Secretion System Inhibitors, Produced by Streptomyces sp. K01-0509". The Journal of Antibiotics. 61 (4): 222–229. doi:10.1038/ja.2008.32. PMID 18503201.
  2. Holmes, T. C.; May, A. E.; Zaleta-Rivera, K.; Ruby, J. G.; Skewes-Cox, P.; Fischbach, M. A.; Derisi, J. L.; Iwatsuki, M.; Ōmura, S.; Khosla, C. (2012). "Molecular Insights into the Biosynthesis of Guadinomine: A Type III Secretion System Inhibitor". Journal of the American Chemical Society. 134 (42): 17797–17806. doi:10.1021/ja308622d. PMC 3483642. PMID 23030602.


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