Gregory L. Verdine

Gregory L. Verdine (born June 10, 1959) is an American chemical biologist, biotech entrepreneur, venture capitalist and university professor[3]. He is a founder of the field of chemical biology, which deals with the application of chemical techniques to biological systems. His work has focused on mechanisms of DNA repair and cell penetrability.

Gregory L. Verdine
Born
Gregory L. Verdine

(1959-06-10) June 10, 1959
Somers Point, New Jersey[1]
NationalityUnited States
CitizenshipUnited States
Alma mater
Known forStapled peptides
Scientific career
FieldsChemical biology[2]
Institutions
ThesisBinding of mitomycin C to a dinucleoside phosphate and DNA (1986)
Doctoral advisorKoji Nakanishi and Maria Tomasz
Notable studentsOrlando D. Schärer

Verdine is the co-inventor with Christian Schafmeister of stapled peptides, a new class of drugs that combines the versatile binding properties of monoclonal antibodies with the cell-penetrating ability of small molecules. Verdine coined the term "drugging the undruggable" to describe the unique capabilities of stapled peptides. A close analog of a stapled peptide drug invented in the Verdine Lab, ALRN-6924, is a first-in-class dual MDM2/MDMX inhibitor currently in Phase II clinical development by Aileron Therapeutics[4], which he co-founded in 2005. FogPharma, founded in 2016, aims to further develop stapled peptide technology for therapeutic use.

He has founded numerous other drug discovery companies, including six that are listed on the NASDAQ. His companies have succeeded in developing two FDA-approved drugs, Romidepsin and Paritaprevir, which are, respectively, an anticancer agent used in cutaneous T-cell lymphoma (CTCL) and other peripheral T-cell lymphomas (PTCLs), and an acylsulfonamide inhibitor that is used to treat chronic Hepatitis C.

Education and Training

Verdine received a Bachelor of Science in Chemistry from Saint Joseph's University and a PhD in Chemistry from Columbia University, working under Koji Nakanishi and Maria Tomasz. He held an NIH postdoctoral fellowship in molecular biology at MIT and Harvard Medical School, and joined the faculty of Harvard University in 1988[5].

Academic Career

Over the course of his academic career at Harvard University and the Harvard Medical School, Verdine has elucidated the molecular mechanism of epigenetic DNA methylation and pathways by which certain genotoxic forms of DNA damage are surveilled in and eradicated from the genome.[5] As a professor, Verdine introduced biological principles into organic chemistry courses and helped found two fields of science that meld basic research and new medicines discovery: chemical biology, which enlists chemistry to answer biological questions; and new modalities, which works to discover and develop novel structural classes of therapeutics[6].

He has served as the Erving Professor of Chemistry in the Departments of Stem Cell and Regenerative Biology and Chemistry and Chemical Biology at Harvard University since 1988. In 2013, he stepped down from his tenured professorship at Harvard, taking a leave of absence in order to focus full-time on steering Warp Drive Bio as CEO[7][8] while continuing to run[9] his eponymous Verdine Laboratory at the Harvard University Department of Stem Cell & Regenerative Biology. The laboratory focused on research based in chemical biology, including synthetic biologics and genomic research,[10]. He has since transitioned to a 'professor of the practice' position at Harvard.

Research

In his academic research, Verdine made fundamental discoveries about how organisms manage their genomes: how they tag specific cell types and conduct search-and-destroy operations for cancer-causing abnormalities.[11] Verdine has published more than 190 academic articles.[2][12] In 2005, Verdine and Anirban Banerjee published research in crystallography showing how enzymes could be used to fix flawed DNA.[13] In 2013, Verdine received a research grant to study cell-penetrating miniproteins in order to target cancer cells.[14] His work has led to the FDA approval of the drugs romidepsin and paritaprevir.[5]

Verdine is also the inventor of stapled peptide technology, which stabilizes peptides intended for therapeutic use by introducing an all-hydrocarbon “staple” into the peptide’s linear backbone. These “stapled” peptides have a higher affinity for their targets, enter cells more easily and are less readily degraded. [15]

Biotechnology

Companies

To translate his discoveries into therapeutics, Verdine has founded or co-founded numerous public biotech companies including Variagenics, Enanta, Eleven Bio, Tokai, Wave Life Sciences, and Aileron[16]. He also founded the private company Gloucester Pharmaceuticals, which was acquired by Celgene in 2009[17]. His companies share the mission of developing molecules intended to target “hard-to-drug” endogenous targets that have remained out of reach of modern cell-penetration technologies.[14][18]

FogPharma

In 2016, Verdine co-founded FogPharma with Sir David Lane to develop next-generation stapled peptides, Cell-Penetrating Miniproteins (CPMPs), a broad new class of medicines that aim to combine the cell-penetrating abilities of small molecules with the strong target engagement of biologics[19].

LifeMine

Founded alongside FogPharma in 2016, LifeMine seeks to discover, characterize, and translate into medicine bioactive compounds in fungal genomes[20].

Gloucester Marine Genomics Institute

Founded in 2013, the nonprofit Gloucester Marine Genomics Institute to study marine genomes for potential therapeutic compounds and to advance fisheries science[21]. He is also the founder and director of the Gloucester Biotechnology Academy, which is providing technical training in the life science industry to high school graduates in Gloucester, MA, USA[5].

Warp Drive Bio

In 2012, Verdine founded Warp Drive Bio with cofounders George Church and James Wells[22]. The company maps the genomes of soil-dwelling microbes in the search for potential treatments for drug-resistant ailments. In 2013, Verdine became full-time CEO of Warp Drive Bio[23], then handed the CEO position to Lawrence Reid in 2016[24] in order to found two new startups, FogPharma and LifeMine.

Wave Life Sciences

Verdine is the Chairman of the Board of Wave Life Sciences,[25] which uses synthetic chemistry to develop nucleic acid therapeutic candidates.[26]

Venture Capital

Verdine has worked in the venture capital industry as a Venture Partner with Apple Tree Partners, Third Rock Ventures, and WuXi Healthcare Ventures, and as a Special Advisor to Texas Pacific Group.[27] 

Scientific Consultation

Verdine is a member of both the Board of Scientific Consultants of the Memorial Sloan-Kettering Cancer Center, the Board of Scientific Advisors of the National Cancer Institute,[5] Advisory Board at Spinal Muscular Atrophy Foundation, and the Board of Reviewers at Bill & Melinda Gates Foundation.[28]

Recent Recognition

2019 - Honorary Doctor of Science Degree, Clarkson University[29]

2019 - Herman S. Bloch Award for Scientific Excellence in Industry, University of Chicago[30]

2011 - American Association for Cancer Research Award for Excellence in Chemistry in Cancer Research[31]

2007 - Nobel Laureate Signature Award for Graduate Education in Chemistry, with Anirban Banerjee[32]

2005 - Royal Society of Chemistry Nucleic Acid Award Lecture, Responses to DNA Damage conference[33]

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References
  1. Gregory L. Verdine C.V., Studylib.net. Accessed December 17, 2017. "Born:June 10, 1959, Somers Point, New Jersey, USA"
  2. Gregory L. Verdine publications indexed by Google Scholar
  3. "Gregory Verdine". HSCRB. Retrieved October 25, 2019.
  4. "Clinical Trials". Aileron Therapeutics. Retrieved October 30, 2019.
  5. Gregory Verdine Biography, Harvard University
  6. "Gregory Verdine earns two honors in three days". chemistry.harvard.edu. Retrieved October 25, 2019.
  7. "Xconomy: Harvard Professor Steps Down to Pilot Warp Drive Bio". Xconomy. July 2, 2013. Retrieved October 25, 2019.
  8. "Xconomy: Ex-Alnylam Exec to Steer Warp Drive Bio; Verdine Shifts Roles". Xconomy. March 4, 2015. Retrieved October 25, 2019.
  9. "Xconomy: Ex-Alnylam Exec to Steer Warp Drive Bio; Verdine Shifts Roles". Xconomy. March 4, 2015. Retrieved October 25, 2019.
  10. Verdine Lab, Harvard University
  11. "Gregory Verdine earns two honors in three days". chemistry.harvard.edu. Retrieved October 25, 2019.
  12. PubMed
  13. Amanda Yarnell, Enzyme Finds, Fixes Flawed DNA, Chemical & Engineering News
  14. Ben Fidler, With Latest Startup, Harvard’s Verdine Again Aims at Elusive Targets,Xconomy.com
  15. Amanda Goh, Stapled Peptides: Targeting the "Undruggable", BioIT World
  16. "Gregory Verdine earns two honors in three days". chemistry.harvard.edu. Retrieved October 25, 2019.
  17. "Xconomy: Celgene Agrees to Acquire Gloucester Pharma for $340M Cash Upfront, $300M Later". Xconomy. December 7, 2009. Retrieved October 25, 2019.
  18. Matthew Herper, Can Bush's NIH Chief Fix the Drug Industry, Forbes
  19. "Fogpharma". Fog Pharma. Retrieved October 25, 2019.
  20. "LifeMine – Mining the Medicines of Life". lifeminetx.com. Retrieved October 25, 2019.
  21. Katheleen Conti, Can the nation’s oldest seaport reinvent itself?, Boston Globe
  22. "Warp Drive Bio Launches With $125 Million from Third Rock Ventures, Greylock, Sanofi (France)". BioSpace. Retrieved October 25, 2019.
  23. "Warp Drive Bio Appoints Co-Founder Gregory Verdine, Ph.D., to Chief Executive Officer". FierceBiotech. Retrieved October 25, 2019.
  24. "In conversation with: Laurence Reid, Warp Drive Bio CEO". FierceBiotech. Retrieved October 25, 2019.
  25. Damian Garde,Wave LifeSci Banks $66M with a "Pure" Take on Synthetic Chemistry, FierceBiotech.com
  26. Jessica Moore, Brokerages Expect WAVE Life Sciences Ltd. (NASDAQ:WVE) to Post -$0.75 EPS, The CERBAT GEM
  27. "Gregory Verdine". HSCRB. Retrieved October 28, 2019.
  28. Bloomberg Executive Profile
  29. "Gregory Verdine Awarded Clarkson University Honorary Degree | Clarkson University". www.clarkson.edu. Retrieved October 25, 2019.
  30. "Gregory Verdine earns two honors in three days". chemistry.harvard.edu. Retrieved October 25, 2019.
  31. "AACR Award for Outstanding Achievement in Chemistry in Cancer Research". www.aacr.org. Retrieved October 25, 2019.
  32. "Nobel Laureate Signature Award for Graduate Education in Chemistry". American Chemical Society. Retrieved October 25, 2019.
  33. "Nucleic Acids Group Awards". www.rsc.org. Retrieved October 26, 2019.
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