Glucuronide

A glucuronide, also known as glucuronoside, is any substance produced by linking glucuronic acid to another substance via a glycosidic bond.[1] The glucuronides belong to the glycosides.

Morphine-6-glucuronide, a major metabolite of morphine

Glucuronidation, the conversion of chemical compounds to glucuronides, is a method that animals use to assist in the excretion of toxic substances, drugs or other substances that cannot be used as an energy source. Glucuronic acid is attached via a glycosidic bond to the substance, and the resulting glucuronide, which has a much higher water solubility than the original substance, is eventually excreted by the kidneys.[2]

Enzymes that cleave the glycosidic bond of a glucuronide are called glucuronidases.

Examples

gollark: The big ones, obviously.
gollark: 13x13 has the advantage of being exactly the size of compact machines, you know.
gollark: If you think your base is messy, though, you should see my basement, although you should not see it because it is classified.
gollark: When playing modded, you either build a horrible messy base which works nicely, and intend to build a nice new base "later" but never do properly, or you burn out trying to make your regular base really nice.
gollark: Me too.

References

  1. The American Heritage Medical Dictionary, 2007, Houghton Mifflin Company
  2. Yang G, Ge S, Singh R, Basu S, Shatzer K, Zen M, et al. (May 2017). "Glucuronidation: driving factors and their impact on glucuronide disposition". Drug Metabolism Reviews. 49 (2): 105–138. doi:10.1080/03602532.2017.1293682. PMID 28266877.
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