Glucuronide

A glucuronide, also known as glucuronoside, is any substance produced by linking glucuronic acid to another substance via a glycosidic bond.[1] The glucuronides belong to the glycosides.

Morphine-6-glucuronide, a major metabolite of morphine

Glucuronidation, the conversion of chemical compounds to glucuronides, is a method that animals use to assist in the excretion of toxic substances, drugs or other substances that cannot be used as an energy source. Glucuronic acid is attached via a glycosidic bond to the substance, and the resulting glucuronide, which has a much higher water solubility than the original substance, is eventually excreted by the kidneys.[2]

Enzymes that cleave the glycosidic bond of a glucuronide are called glucuronidases.

Examples

gollark: I know roughly how. It would just be annoying to implement.
gollark: No, this is actually hard.
gollark: Well, moderately easily.
gollark: Oh, wait, I could actually make it work fairly easily.
gollark: I had a DNS to IRC and DNS to comment bridge (unidirectional because streaming would be very hard).

References

  1. The American Heritage Medical Dictionary, 2007, Houghton Mifflin Company
  2. Yang G, Ge S, Singh R, Basu S, Shatzer K, Zen M, et al. (May 2017). "Glucuronidation: driving factors and their impact on glucuronide disposition". Drug Metabolism Reviews. 49 (2): 105–138. doi:10.1080/03602532.2017.1293682. PMID 28266877.
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