Big gastrin

Big gastrin (G-34) is a form of gastrin with 34 amino acids in its sequence. Big gastrin is a hormone produced by G cells and can be found inside of the stomach.[1] G-34 promotes the secretion of gastric acid in dogs.[2] In dogs, the half life of this peptide is between 14.7 and 16.8 minutes.[3] In humans, an over production of this hormone by gastrinomas leads to Zollinger-Ellison Syndrome.[4]

Big Gastrin

Names
IUPAC name H-Pyr-Leu-Gly-Gly-Gln-Gly-Pro-Gly-Gly-Gly-Gly-Ala-Asp-Gly-Gly-Lys-Lys-Gln-Gly-Pro-Gly-Gly-Glu-Glu-Glu-Glu-Gly-Ala-Gly-Gly-Trp-Met-Asp-Phe-NH2
Systematic IUPAC name L-pyroglutamyl-L-leucyl-glycyl-glycyl-L-glutaminyl-glycyl-L-prolyl-glycyl-glycyl-glycyl-glycyl-L-alanyl-L-alpha-aspartyl-glycyl-glycyl-L-lysyl-L-lysyl-L-glutaminyl-glycyl-L-prolyl-glycyl-glycyl-L-alpha-glutamyl-L-alpha-glutamyl-L-alpha-glutamyl-L-alpha-glutamyl-glycyl-L-alanyl-glycyl-glycyl-L-tryptophyl-L-methionyl-L-alpha-aspartyl-L-phenylalaninamide
Other names Pro-gastrin, Big-Gastrin, G-34, Gastrin-34
Identifiers
CAS Number	53988-98-0^Y
3D model (JSmol)	Interactive image
ChEBI	CHEBI:75437^N
ChemSpider	17288965^Y
PubChem CID	16132306
InChI InChI=1S/C132H194N40O49S/c1-66(2)45-84(169-125(214)78-27-34-92(175)156-78)120(209)147-54-96(179)143-60-103(186)158-75(25-32-90(135)173)117(206)152-64-106(189)171-42-15-23-88(171)131(220)150-56-98(181)140-51-93(176)139-52-94(177)141-58-100(183)155-68(4)116(205)168-86(48-112(199)200)121(210)148-55-97(180)142-59-102(185)157-73(21-11-13-40-133)122(211)161-74(22-12-14-41-134)123(212)162-76(26-33-91(136)174)119(208)153-65-107(190)172-43-16-24-89(172)132(221)151-57-99(182)144-61-104(187)159-79(29-36-109(193)194)124(213)164-81(31-38-111(197)198)127(216)165-80(30-37-110(195)196)126(215)163-77(28-35-108(191)192)118(207)149-63-101(184)154-67(3)115(204)146-53-95(178)145-62-105(188)160-85(47-70-50-138-72-20-10-9-19-71(70)72)129(218)166-82(39-44-222-5)128(217)170-87(49-113(201)202)130(219)167-83(114(137)203)46-69-17-7-6-8-18-69/h6-10,17-20,50,66-68,73-89,138H,11-16,21-49,51-65,133-134H2,1-5H3,(H2,135,173)(H2,136,174)(H2,137,203)(H,139,176)(H,140,181)(H,141,177)(H,142,180)(H,143,179)(H,144,182)(H,145,178)(H,146,204)(H,147,209)(H,148,210)(H,149,207)(H,150,220)(H,151,221)(H,152,206)(H,153,208)(H,154,184)(H,155,183)(H,156,175)(H,157,185)(H,158,186)(H,159,187)(H,160,188)(H,161,211)(H,162,212)(H,163,215)(H,164,213)(H,165,216)(H,166,218)(H,167,219)(H,168,205)(H,169,214)(H,170,217)(H,191,192)(H,193,194)(H,195,196)(H,197,198)(H,199,200)(H,201,202)/t67-,68-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-/m0/s1^Y Key: RZIMNEGTIDYAGZ-HNSJZBNRSA-N^Y InChI=1/C132H194N40O49S/c1-66(2)45-84(169-125(214)78-27-34-92(175)156-78)120(209)147-54-96(179)143-60-103(186)158-75(25-32-90(135)173)117(206)152-64-106(189)171-42-15-23-88(171)131(220)150-56-98(181)140-51-93(176)139-52-94(177)141-58-100(183)155-68(4)116(205)168-86(48-112(199)200)121(210)148-55-97(180)142-59-102(185)157-73(21-11-13-40-133)122(211)161-74(22-12-14-41-134)123(212)162-76(26-33-91(136)174)119(208)153-65-107(190)172-43-16-24-89(172)132(221)151-57-99(182)144-61-104(187)159-79(29-36-109(193)194)124(213)164-81(31-38-111(197)198)127(216)165-80(30-37-110(195)196)126(215)163-77(28-35-108(191)192)118(207)149-63-101(184)154-67(3)115(204)146-53-95(178)145-62-105(188)160-85(47-70-50-138-72-20-10-9-19-71(70)72)129(218)166-82(39-44-222-5)128(217)170-87(49-113(201)202)130(219)167-83(114(137)203)46-69-17-7-6-8-18-69/h6-10,17-20,50,66-68,73-89,138H,11-16,21-49,51-65,133-134H2,1-5H3,(H2,135,173)(H2,136,174)(H2,137,203)(H,139,176)(H,140,181)(H,141,177)(H,142,180)(H,143,179)(H,144,182)(H,145,178)(H,146,204)(H,147,209)(H,148,210)(H,149,207)(H,150,220)(H,151,221)(H,152,206)(H,153,208)(H,154,184)(H,155,183)(H,156,175)(H,157,185)(H,158,186)(H,159,187)(H,160,188)(H,161,211)(H,162,212)(H,163,215)(H,164,213)(H,165,216)(H,166,218)(H,167,219)(H,168,205)(H,169,214)(H,170,217)(H,191,192)(H,193,194)(H,195,196)(H,197,198)(H,199,200)(H,201,202)/t67-,68-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-/m0/s1 Key: RZIMNEGTIDYAGZ-HNSJZBNRBP
SMILES CC(C)CC(C(=O)NCC(=O)NCC(=O)NC(CCC(=O)N)C(=O)NCC(=O)N1CCCC1C(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NC(C)C(=O)NC(CC(=O)O)C(=O)NCC(=O)NCC(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCC(=O)N)C(=O)NCC(=O)N2CCCC2C(=O)NCC(=O)NCC(=O)NC(CCC(=O)O)C(=O)NC(CCC(=O)O)C(=O)NC(CCC(=O)O)C(=O)NC(CCC(=O)O)C(=O)NCC(=O)NC(C)C(=O)NCC(=O)NCC(=O)NC(Cc3c[nH]c4c3cccc4)C(=O)NC(CCSC)C(=O)NC(CC(=O)O)C(=O)NC(Cc5ccccc5)C(=O)N)NC(=O)C6CCC(=O)N6
Properties
Chemical formula	C132H194N40O49S
Molar mass	3157.26 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

References

1. Johnson, Gareth J. (2007-06-19). "Oxford Dictionary of Biochemistry and Molecular Biology (2nd edition)2007235Edited by Richard Cammack and others. Oxford Dictionary of Biochemistry and Molecular Biology (2nd edition). Oxford: Oxford University Press 2006. xv+720 pp., £49.95 $89.50". Reference Reviews. 21 (5): 41–42. doi:10.1108/09504120710755635. ISBN 978-0-19-852917-0. ISSN 0950-4125.
2. Walsh, J. H; Debas, H. T; Grossman, M. I (1974). "Pure human big gastrin. Immunochemical properties, disappearance half time, and acid-stimulating action in dogs". The Journal of Clinical Investigation. 54 (2): 477–85. doi:10.1172/JCI107783. PMC 301575. PMID 4847254.
3. Walsh, John H.; Debas, Haile T.; Grossman, Morton I. (1974-08-01). "Pure Human Big Gastrin IMMUNOCHEMICAL PROPERTIES, DISAPPEARANCE HALF TIME, AND ACID-STIMULATING ACTION IN DOGS". Journal of Clinical Investigation. 54 (2): 480. doi:10.1172/jci107783. ISSN 0021-9738. PMC 301575. PMID 4847254.
4. National Digestive Diseases Information Clearinghouse (U.S.) (2009). Digestive diseases dictionary. U.S. Dept. of Health and Human Services, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, National Digestive Diseases Information Clearinghouse. OCLC 44203071.