G protein nucleolar 3 like

G protein nucleolar 3 like is a protein that in humans is encoded by the GNL3L gene.[5]

GNL3L
Identifiers
Aliases	GNL3L, GNL3B, G protein nucleolar 3 like
External IDs	OMIM: 300873 MGI: 2448557 HomoloGene: 134538 GeneCards: GNL3L
Gene location (Human) Chr. X chromosome (human)[1] Band Xp11.22 Start 54,530,211 bp[1] End 54,567,289 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X F3 Start 150,983,141 bp[2] End 151,017,322 bp[2]
Gene ontology Molecular function • GO:0001948 protein binding • nucleotide binding • GTP binding • RNA binding • GTPase activity Cellular component • cell nucleus • telomerase holoenzyme complex • membrane • nucleolus • cytosol Biological process • regulation of protein stability • negative regulation of telomere maintenance via telomerase • positive regulation of protein homodimerization activity • negative regulation of protein sumoylation • positive regulation of protein localization to chromosome, telomeric region • negative regulation of protein ubiquitination • negative regulation of protein binding • ribosome biogenesis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	54552	237107
Ensembl	ENSG00000130119	ENSMUSG00000025266
UniProt	Q9NVN8	Q6PGG6
RefSeq (mRNA)	NM_001184819 NM_019067	NM_001168600 NM_198110
RefSeq (protein)	NP_001171748 NP_061940	NP_001162071 NP_932778
Location (UCSC)	Chr X: 54.53 – 54.57 Mb	Chr X: 150.98 – 151.02 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene appears to be a nucleolar GTPase that is essential for ribosomal pre-rRNA processing and cell proliferation. Two transcript variants encoding the same protein have been found for this gene.

References

1. GRCh38: Ensembl release 89: ENSG00000130119 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025266 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: G protein nucleolar 3 like". Retrieved 2017-10-23.

Further reading

• Du X, Rao MR, Chen XQ, Wu W, Mahalingam S, Balasundaram D (2006). "The homologous putative GTPases Grn1p from fission yeast and the human GNL3L are required for growth and play a role in processing of nucleolar pre-rRNA". Mol. Biol. Cell. 17 (1): 460–74. doi:10.1091/mbc.E05-09-0848. PMC 1345682. PMID 16251348.
• Rao MR, Kumari G, Balasundaram D, Sankaranarayanan R, Mahalingam S (2006). "A novel lysine-rich domain and GTP binding motifs regulate the nucleolar retention of human guanine nucleotide binding protein, GNL3L". J. Mol. Biol. 364 (4): 637–54. doi:10.1016/j.jmb.2006.09.007. PMID 17034816.
• Oktar PA, Yildirim S, Balci D, Can A (2011). "Continual expression throughout the cell cycle and downregulation upon adipogenic differentiation makes nucleostemin a vital human MSC proliferation marker". Stem Cell Rev. 7 (2): 413–24. doi:10.1007/s12015-010-9201-y. PMID 21063916.
• Meng L, Hsu JK, Tsai RY (2011). "GNL3L depletion destabilizes MDM2 and induces p53-dependent G2/M arrest". Oncogene. 30 (14): 1716–26. doi:10.1038/onc.2010.550. PMC 3072457. PMID 21132010.
• Lin T, Meng L, Lin TC, Wu LJ, Pederson T, Tsai RY (2014). "Nucleostemin and GNL3L exercise distinct functions in genome protection and ribosome synthesis, respectively". J. Cell Sci. 127 (Pt 10): 2302–12. doi:10.1242/jcs.143842. PMC 6519424. PMID 24610951.
• Thoompumkal IJ, Subba Rao MR, Kumaraswamy A, Krishnan R, Mahalingam S (2015). "GNL3L Is a Nucleo-Cytoplasmic Shuttling Protein: Role in Cell Cycle Regulation". PLoS ONE. 10 (8): e0135845. doi:10.1371/journal.pone.0135845. PMC 4537249. PMID 26274615.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.