GZMH

Granzyme H is a protein that in humans is encoded by the GZMH gene.[5][6]

GZMH
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3TJU, 3TJV, 3TK9, 4GAW
Identifiers
Aliases	GZMH, CCP-X, CGL-2, CSP-C, CTLA1, CTSGL2, granzyme H
External IDs	OMIM: 116831 MGI: 109254 HomoloGene: 133275 GeneCards: GZMH
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q12 Start 24,606,480 bp[1] End 24,609,699 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14 C3|14 28.19 cM Start 56,205,263 bp[2] End 56,211,417 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • peptidase activity • serine-type peptidase activity • serine-type endopeptidase activity • hydrolase activity Cellular component • membrane • secretory granule • cytoplasm Biological process • cytolysis • apoptotic process • proteolysis • granzyme-mediated apoptotic signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2999	14943
Ensembl	ENSG00000100450	ENSMUSG00000015441
UniProt	P20718	P08883
RefSeq (mRNA)	NM_001270780 NM_001270781 NM_033423	NM_010374
RefSeq (protein)	NP_001257709 NP_001257710 NP_219491	NP_034504
Location (UCSC)	Chr 14: 24.61 – 24.61 Mb	Chr 14: 56.21 – 56.21 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000100450 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000015441 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Haddad P, Jenne D, Tschopp J, Clement MV, Mathieu-Mahul D, Sasportes M (Jul 1991). "Structure and evolutionary origin of the human granzyme H gene" (PDF). Int Immunol. 3 (1): 57–66. doi:10.1093/intimm/3.1.57. PMID 2049336.
6. "Entrez Gene: GZMH granzyme H (cathepsin G-like 2, protein h-CCPX)".

Further reading

• Waterhouse NJ, Trapani JA (2007). "H is for helper: granzyme H helps granzyme B kill adenovirus-infected cells". Trends Immunol. 28 (9): 373–5. doi:10.1016/j.it.2007.08.001. PMID 17766182.
• Llorens C, Martres MP, Baudry M, Schwartz JC (1978). "Hypersensitivity to noradrenaline in cortex after chronic morphine: relevance to tolerance and dependence". Nature. 274 (5671): 603–5. doi:10.1038/274603a0. PMID 209336.
• Heusel JW, Hanson RD, Silverman GA, Ley TJ (1991). "Structure and expression of a cluster of human hematopoietic serine protease genes found on chromosome 14q11.2". J. Biol. Chem. 266 (10): 6152–8. PMID 2007574.
• Meier M, Kwong PC, Frégeau CJ, et al. (1990). "Cloning of a gene that encodes a new member of the human cytotoxic cell protease family". Biochemistry. 29 (17): 4042–9. doi:10.1021/bi00469a003. PMID 2193684.
• Hanson RD, Hohn PA, Popescu NC, Ley TJ (1990). "A cluster of hematopoietic serine protease genes is found on the same chromosomal band as the human alpha/delta T-cell receptor locus". Proc. Natl. Acad. Sci. U.S.A. 87 (3): 960–3. doi:10.1073/pnas.87.3.960. PMC 53389. PMID 2300587.
• Klein JL, Selvakumar A, Trapani JA, Dupont B (1990). "Characterization of a novel, human cytotoxic lymphocyte-specific serine protease cDNA clone (CSP-C)". Tissue Antigens. 35 (5): 220–8. doi:10.1111/j.1399-0039.1990.tb01787.x. PMID 2402757.
• MacIvor DM, Pham CT, Ley TJ (1999). "The 5' flanking region of the human granzyme H gene directs expression to T/natural killer cell progenitors and lymphokine-activated killer cells in transgenic mice". Blood. 93 (3): 963–73. PMID 9920846.
• Edwards KM, Kam CM, Powers JC, Trapani JA (1999). "The human cytotoxic T cell granule serine protease granzyme H has chymotrypsin-like (chymase) activity and is taken up into cytoplasmic vesicles reminiscent of granzyme B-containing endosomes". J. Biol. Chem. 274 (43): 30468–73. doi:10.1074/jbc.274.43.30468. PMID 10521426.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Johnson H, Scorrano L, Korsmeyer SJ, Ley TJ (2003). "Cell death induced by granzyme C". Blood. 101 (8): 3093–101. doi:10.1182/blood-2002-08-2485. PMID 12515723.
• Sedelies KA, Sayers TJ, Edwards KM, et al. (2004). "Discordant regulation of granzyme H and granzyme B expression in human lymphocytes". J. Biol. Chem. 279 (25): 26581–7. doi:10.1074/jbc.M312481200. PMID 15069086.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Andrade F, Fellows E, Jenne DE, et al. (2007). "Granzyme H destroys the function of critical adenoviral proteins required for viral DNA replication and granzyme B inhibition". EMBO J. 26 (8): 2148–57. doi:10.1038/sj.emboj.7601650. PMC 1852776. PMID 17363894.
• Fellows E, Gil-Parrado S, Jenne DE, Kurschus FC (2007). "Natural killer cell-derived human granzyme H induces an alternative, caspase-independent cell-death program". Blood. 110 (2): 544–52. doi:10.1182/blood-2006-10-051649. PMID 17409270.