GVD (chemotherapy)
GVD is a chemotherapy regimen, used for salvage treatment of relapsed or refractory Hodgkin disease, including those patients who relapse after stem cell transplantation.[1]
GVD regimen consists of three drugs:
- (G)emcitabine
- (V)inorelbine
- (D)oxil - pegylated liposomal formulation of doxorubicin
Dosing
Drug | Dose in transplant-naive patients | Dose in post-transplant patients | Mode | Days | |
---|---|---|---|---|---|
(G)emcitabine | 1000 mg/m2 | 800 mg/m2 | IV infusion | Days 1, 8 | |
(V)inorelbine | 20 mg/m2 | 15 mg/m2 | IV bolus | Days 1, 8 | |
(D)oxil | 15 mg/m2 | 10 mg/m2 | IV infusion | Days 1, 8 | |
Repeated every 21 days (3 weeks).
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