GVD (chemotherapy)

GVD is a chemotherapy regimen, used for salvage treatment of relapsed or refractory Hodgkin disease, including those patients who relapse after stem cell transplantation.[1]

GVD regimen consists of three drugs:

(G)emcitabine
(V)inorelbine
(D)oxil - pegylated liposomal formulation of doxorubicin

Dosing

Drug	Dose in transplant-naive patients	Dose in post-transplant patients	Mode	Days
(G)emcitabine	1000 mg/m²	800 mg/m²	IV infusion	Days 1, 8
(V)inorelbine	20 mg/m²	15 mg/m²	IV bolus	Days 1, 8
(D)oxil	15 mg/m²	10 mg/m²	IV infusion	Days 1, 8

Repeated every 21 days (3 weeks).

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References

Gemcitabine, vinorelbine, and pegylated liposomal doxorubicin (GVD), a salvage regimen in relapsed Hodgkin's lymphoma: CALGB 59804

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[1] Gemcitabine, vinorelbine, and pegylated liposomal doxorubicin (GVD), a salvage regimen in relapsed Hodgkin's lymphoma: CALGB 59804