GSTT1

Glutathione S-transferase theta-1 is an enzyme that in humans is encoded by the GSTT1 gene.[2]

GSTT1
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesGSTT1, glutathione S-transferase theta 1
External IDsOMIM: 600436 GeneCards: GSTT1
Gene location (Human)
Chr.Chromosome 22 (human)
Band22q11.23Start24,376,133 bp
End24,384,680 bp
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

2952

n/a

Ensembl

ENSG00000277656

n/a

UniProt

P30711

n/a

RefSeq (mRNA)

n/a

RefSeq (protein)

n/a

Location (UCSC)Chr 22: 24.38 – 24.38 Mbn/a
PubMed search[1]n/a
Wikidata
View/Edit Human

Glutathione S-transferase (GST) theta 1 (GSTT1) is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1 and GSTT2. The GSTT1 and GSTT2 share 55% amino acid sequence identity and both of them were claimed to have an important role in human carcinogenesis. The GSTT1 gene is located approximately 50kb away from the GSTT2 gene. The GSTT1 and GSTT2 genes have a similar structure, being composed of five exons with identical exon/intron boundaries.[3]


References
  1. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  2. Webb G, Vaska V, Coggan M, Board P (Jun 1996). "Chromosomal localization of the gene for the human theta class glutathione transferase (GSTT1)". Genomics. 33 (1): 121–3. doi:10.1006/geno.1996.0167. PMID 8617495.
  3. "Entrez Gene: GSTT1 glutathione S-transferase theta 1".
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