GSTO2

Glutathione S-transferase omega-2 is an enzyme that in humans is encoded by the GSTO2 gene.[5][6]

GSTO2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3Q18, 3Q19, 3QAG
Identifiers
Aliases	GSTO2, GSTO 2-2, bA127L20.1, glutathione S-transferase omega 2
External IDs	OMIM: 612314 MGI: 1915464 HomoloGene: 57057 GeneCards: GSTO2
EC number	1.8.5.1
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q25.1 Start 104,268,873 bp[1] End 104,304,950 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 D1 Start 47,865,534 bp[2] End 47,886,324 bp[2]
Gene ontology Molecular function • transferase activity • oxidoreductase activity • methylarsonate reductase activity • GO:0001948 protein binding • glutathione dehydrogenase (ascorbate) activity • identical protein binding • glutathione transferase activity Cellular component • cytosol • extracellular exosome • cytoplasm Biological process • metabolism • oxidation-reduction process • cellular response to arsenic-containing substance • glutathione derivative biosynthetic process • L-ascorbic acid metabolic process • xenobiotic metabolic process • cellular oxidant detoxification • glutathione metabolic process • toxin catabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	119391	68214
Ensembl	ENSG00000065621	ENSMUSG00000025069
UniProt	Q9H4Y5	Q8K2Q2
RefSeq (mRNA)	NM_001191013 NM_001191014 NM_001191015 NM_183239	NM_026619 NM_030051
RefSeq (protein)	NP_001177942 NP_001177943 NP_001177944 NP_899062	NP_080895 NP_084327
Location (UCSC)	Chr 10: 104.27 – 104.3 Mb	Chr 19: 47.87 – 47.89 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Model organisms

Model organisms have been used in the study of GSTO2 function. A conditional knockout mouse line called Gsto2^{tm2a(KOMP)Wtsi} was generated at the Wellcome Trust Sanger Institute.[7] Male and female animals underwent a standardized phenotypic screen[8] to determine the effects of deletion.[9][10][11][12] Additional screens performed: - In-depth immunological phenotyping[13]

Gsto2 knockout mouse phenotype

Characteristic	Phenotype
All data available at.[8][13]
Peripheral blood leukocytes 6 Weeks	Normal
Haematology 6 Weeks	Normal
Insulin	Normal
Homozygous viability at P14	Normal
Homozygous Fertility	Normal
Body weight	Normal
Neurological assessment	Normal
Grip strength	Normal
Dysmorphology	Normal
Indirect calorimetry	Normal
Glucose tolerance test	Normal
Auditory brainstem response	Normal
DEXA	Normal
Radiography	Normal
Eye morphology	Normal
Clinical chemistry	Normal
Haematology 16 Weeks	Normal
Peripheral blood leukocytes 16 Weeks	Normal
Heart weight	Normal
Salmonella infection	Normal
Cytotoxic T Cell Function	Normal
Epidermal Immune Composition	Abnormal
Influenza Challenge	Normal

References

1. GRCh38: Ensembl release 89: ENSG00000065621 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025069 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Whitbread AK, Tetlow N, Eyre HJ, Sutherland GR, Board PG (Mar 2003). "Characterization of the human Omega class glutathione transferase genes and associated polymorphisms". Pharmacogenetics. 13 (3): 131–44. doi:10.1097/00008571-200303000-00003. PMID 12618591.
6. "Entrez Gene: GSTO2 glutathione S-transferase omega 2".
7. Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x.
8. "International Mouse Phenotyping Consortium".
9. Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
10. Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
11. Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
12. White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP (Jul 2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell. 154 (2): 452–64. doi:10.1016/j.cell.2013.06.022. PMC 3717207. PMID 23870131.
13. "Infection and Immunity Immunophenotyping (3i) Consortium".

Further reading

• White DL, Li D, Nurgalieva Z, El-Serag HB (Feb 2008). "Genetic variants of glutathione S-transferase as possible risk factors for hepatocellular carcinoma: a HuGE systematic review and meta-analysis". American Journal of Epidemiology. 167 (4): 377–89. doi:10.1093/aje/kwm315. PMID 18065725.
• Calarco JA, Xing Y, Cáceres M, Calarco JP, Xiao X, Pan Q, Lee C, Preuss TM, Blencowe BJ (Nov 2007). "Global analysis of alternative splicing differences between humans and chimpanzees". Genes & Development. 21 (22): 2963–75. doi:10.1101/gad.1606907. PMC 2049197. PMID 17978102.
• Leite JL, Morari EC, Granja F, Campos GM, Guilhen AC, Ward LS (Mar 2007). "Influence of the glutathione s-transferase gene polymorphisms on the susceptibility to basal cell skin carcinoma". Revista Médica de Chile. 135 (3): 301–6. doi:10.4067/s0034-98872007000300004. PMID 17505575.
• Wahner AD, Glatt CE, Bronstein JM, Ritz B (Feb 2007). "Glutathione S-transferase mu, omega, pi, and theta class variants and smoking in Parkinson's disease". Neuroscience Letters. 413 (3): 274–8. doi:10.1016/j.neulet.2006.11.053. PMC 1864949. PMID 17194543.
• Morari EC, Lima AB, Bufalo NE, Leite JL, Granja F, Ward LS (Aug 2006). "Role of glutathione-S-transferase and codon 72 of P53 genotypes in epithelial ovarian cancer patients". Journal of Cancer Research and Clinical Oncology. 132 (8): 521–8. doi:10.1007/s00432-006-0099-3. PMID 16788846.
• Pongstaporn W, Rochanawutanon M, Wilailak S, Linasamita V, Weerakiat S, Petmitr S (Mar 2006). "Genetic alterations in chromosome 10q24.3 and glutathione S-transferase omega 2 gene polymorphism in ovarian cancer". Journal of Experimental & Clinical Cancer Research. 25 (1): 107–14. PMID 16761626.
• Marahatta SB, Punyarit P, Bhudisawasdi V, Paupairoj A, Wongkham S, Petmitr S (May 2006). "Polymorphism of glutathione S-transferase omega gene and risk of cancer". Cancer Letters. 236 (2): 276–81. doi:10.1016/j.canlet.2005.05.020. PMID 15992993.
• Wang L, Xu J, Ji C, Gu S, Lv Y, Li S, Xu Y, Xie Y, Mao Y (Jul 2005). "Cloning, expression and characterization of human glutathione S-transferase Omega 2". International Journal of Molecular Medicine. 16 (1): 19–27. doi:10.3892/ijmm.16.1.19. PMID 15942673.
• Ozturk A, Desai PP, Minster RL, Dekosky ST, Kamboh MI (2005). "Three SNPs in the GSTO1, GSTO2 and PRSS11 genes on chromosome 10 are not associated with age-at-onset of Alzheimer's disease". Neurobiology of Aging. 26 (8): 1161–5. doi:10.1016/j.neurobiolaging.2004.11.001. PMID 15917099.
• Whitbread AK, Mellick GD, Silburn PA, Le Couteur DG, Board PG (May 2004). "Glutathione transferase Omega class polymorphisms in Parkinson disease". Neurology. 62 (10): 1910–1. doi:10.1212/01.wnl.0000125282.09308.b1. PMID 15159516.
• Arning L, Jagiello P, Wieczorek S, Saft C, Andrich J, Epplen JT (Mar 2004). "Glutathione S-Transferase Omega 1 variation does not influence age at onset of Huntington's disease". BMC Medical Genetics. 5: 7. doi:10.1186/1471-2350-5-7. PMC 394327. PMID 15040808.