GRIP1 (gene)

Glutamate receptor-interacting protein 1 is a protein that in humans is encoded by the GRIP1 gene.[5][6]

GRIP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2JIL
Identifiers
Aliases	GRIP1, GRIP, glutamate receptor interacting protein 1, FRASRS3
External IDs	OMIM: 604597 MGI: 1921303 HomoloGene: 12938 GeneCards: GRIP1
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q14.3 Start 66,347,431 bp[1] End 67,069,162 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 D2|10 67.33 cM Start 119,453,830 bp[2] End 120,087,261 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • beta-catenin binding • GO:0001105 transcription coactivator activity • protein C-terminus binding • GO:0001948 protein binding • androgen receptor binding • glucocorticoid receptor binding • receptor signaling complex scaffold activity Cellular component • recycling endosome • cytosol • postsynaptic membrane • membrane • cell membrane • synapse • cell junction • dendrite • endoplasmic reticulum • membrane raft • neuron projection • cytoplasmic vesicle • glutamatergic synapse Biological process • protein localization • androgen receptor signaling pathway • GO:0007243 intracellular signal transduction • dendrite development • positive regulation of transcription, DNA-templated • neurotransmitter receptor transport, endosome to postsynaptic membrane • vesicle-mediated transport in synapse • positive regulation of neuron projection arborization • positive regulation of signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23426	74053
Ensembl	ENSG00000155974	ENSMUSG00000034813
UniProt	Q9Y3R0	Q925T6
RefSeq (mRNA)	NM_001178074 NM_021150 NM_001366722 NM_001366723 NM_001366724 NM_001379345 NM_001379346 NM_001379347 NM_001379348 NM_001379349 NM_001379351	NM_001277292 NM_001277293 NM_001277294 NM_001277295 NM_028736 NM_130891 NM_133442 NM_001358809 NM_001358810 NM_001358811
RefSeq (protein)	NP_001171545 NP_066973 NP_001353651 NP_001353652 NP_001353653 NP_001366274 NP_001366275 NP_001366276 NP_001366277 NP_001366278 NP_001366280	NP_001264221 NP_001264222 NP_001264223 NP_001264224 NP_083012 NP_570961 NP_597699 NP_001345738 NP_001345739 NP_001345740
Location (UCSC)	Chr 12: 66.35 – 67.07 Mb	Chr 10: 119.45 – 120.09 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

GRIP1 (gene) has been shown to interact with:

• GRM3,[7]
• GRIA2,[7]
• GRIA3,[7]
• GRIA4,[7]
• GRIK2,[7][8] and
• GRIK3.[9]

References

1. GRCh38: Ensembl release 89: ENSG00000155974 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000034813 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Bruckner K, Pablo Labrador J, Scheiffele P, Herb A, Seeburg PH, Klein R (April 1999). "EphrinB ligands recruit GRIP family PDZ adaptor proteins into raft membrane microdomains". Neuron. 22 (3): 511–24. doi:10.1016/S0896-6273(00)80706-0. PMID 10197531.
6. "Entrez Gene: GRIP1 glutamate receptor interacting protein 1".
7. Hirbec H, Perestenko O, Nishimune A, Meyer G, Nakanishi S, Henley JM, Dev KK (May 2002). "The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs". J. Biol. Chem. 277 (18): 15221–4. doi:10.1074/jbc.C200112200. PMID 11891216.
8. Hirbec H, Francis JC, Lauri SE, Braithwaite SP, Coussen F, Mulle C, Dev KK, Coutinho V, Meyer G, Isaac JT, Collingridge GL, Henley JM, Couthino V (February 2003). "Rapid and differential regulation of AMPA and kainate receptors at hippocampal mossy fibre synapses by PICK1 and GRIP". Neuron. 37 (4): 625–38. doi:10.1016/S0896-6273(02)01191-1. PMC 3314502. PMID 12597860.
9. Ye B, Liao D, Zhang X, Zhang P, Dong H, Huganir RL (June 2000). "GRASP-1: a neuronal RasGEF associated with the AMPA receptor/GRIP complex". Neuron. 26 (3): 603–17. doi:10.1016/S0896-6273(00)81198-8. PMID 10896157.

Further reading

• Irvine RA, Ma H, Yu MC, et al. (2000). "Inhibition of p160-mediated coactivation with increasing androgen receptor polyglutamine length". Hum. Mol. Genet. 9 (2): 267–74. doi:10.1093/hmg/9.2.267. PMID 10607837.
• Teyssier C, Belguise K, Galtier F, Chalbos D (2001). "Characterization of the physical interaction between estrogen receptor alpha and JUN proteins". J. Biol. Chem. 276 (39): 36361–9. doi:10.1074/jbc.M101806200. PMID 11477071.
• Lin SH, Arai AC, Wang Z, et al. (2001). "The carboxyl terminus of the prolactin-releasing peptide receptor interacts with PDZ domain proteins involved in alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor clustering". Mol. Pharmacol. 60 (5): 916–23. doi:10.1124/mol.60.5.916. PMID 11641419. S2CID 9613515.
• Hirbec H, Perestenko O, Nishimune A, et al. (2002). "The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs". J. Biol. Chem. 277 (18): 15221–4. doi:10.1074/jbc.C200112200. PMID 11891216.
• Braithwaite SP, Xia H, Malenka RC (2002). "Differential roles for NSF and GRIP/ABP in AMPA receptor cycling". Proc. Natl. Acad. Sci. U.S.A. 99 (10): 7096–101. doi:10.1073/pnas.102156099. PMC 124534. PMID 12011465.
• Kotaja N, Karvonen U, Jänne OA, Palvimo JJ (2002). "The nuclear receptor interaction domain of GRIP1 is modulated by covalent attachment of SUMO-1". J. Biol. Chem. 277 (33): 30283–8. doi:10.1074/jbc.M204768200. PMID 12060666.
• Min G, Kim H, Bae Y, et al. (2002). "Inhibitory cross-talk between estrogen receptor (ER) and constitutively activated androstane receptor (CAR). CAR inhibits ER-mediated signaling pathway by squelching p160 coactivators". J. Biol. Chem. 277 (37): 34626–33. doi:10.1074/jbc.M205239200. PMID 12114525.
• Coutts AS, MacKenzie E, Griffith E, Black DM (2003). "TES is a novel focal adhesion protein with a role in cell spreading". J. Cell Sci. 116 (Pt 5): 897–906. doi:10.1242/jcs.00278. PMID 12571287.
• Charych EI, Yu W, Li R, et al. (2004). "A four PDZ domain-containing splice variant form of GRIP1 is localized in GABAergic and glutamatergic synapses in the brain". J. Biol. Chem. 279 (37): 38978–90. doi:10.1074/jbc.M405786200. PMID 15226318.
• Sugatani J, Nishitani S, Yamakawa K, et al. (2005). "Transcriptional regulation of human UGT1A1 gene expression: activated glucocorticoid receptor enhances constitutive androstane receptor/pregnane X receptor-mediated UDP-glucuronosyltransferase 1A1 regulation with glucocorticoid receptor-interacting protein 1". Mol. Pharmacol. 67 (3): 845–55. doi:10.1124/mol.104.007161. PMID 15557560. S2CID 5742622.
• Lin DY, Fang HI, Ma AH, et al. (2004). "Negative Modulation of Androgen Receptor Transcriptional Activity by Daxx". Mol. Cell. Biol. 24 (24): 10529–41. doi:10.1128/MCB.24.24.10529-10541.2004. PMC 533990. PMID 15572661.
• Yang CK, Kim JH, Li H, Stallcup MR (2006). "Differential use of functional domains by CoCoA in its synergistic coactivator function with β-catenin or GRIP1". J. Biol. Chem. 281 (6): 3389–97. doi:10.1074/jbc.M510403200. PMC 1626527. PMID 16344550.
• Liu PY, Hsieh TY, Chou WY, Huang SM (2006). "Modulation of glucocorticoid receptor-interacting protein 1 (GRIP1) transactivation and co-activation activities through its C-terminal repression and self-association domains". FEBS J. 273 (10): 2172–83. doi:10.1111/j.1742-4658.2006.05231.x. PMID 16649994.
• Tsai SJ, Liou YJ, Liao DL, et al. (2007). "No association of GRIP1 gene polymorphisms with schizophrenia in Chinese population". Prog. Neuropsychopharmacol. Biol. Psychiatry. 31 (3): 752–5. doi:10.1016/j.pnpbp.2007.01.015. PMID 17303296.

External links

• Overview of all the structural information available in the PDB for UniProt: Q9Y3R0 (Human Glutamate receptor-interacting protein) at the PDBe-KB.
• Overview of all the structural information available in the PDB for UniProt: Q925T6 (Mouse Glutamate receptor-interacting protein) at the PDBe-KB.