GRAMD4

GRAMD4
Identifiers
Aliases	GRAMD4, DIP, dA59H18.1, dJ439F8.1, GRAM domain containing 4
External IDs	OMIM: 613691 MGI: 2676308 HomoloGene: 18199 GeneCards: GRAMD4
Gene location (Human)
Chr.	Chromosome 22 (human)[1]
End	46,679,790 bp[1]
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)[2]
End	86,137,634 bp[2]
Gene ontology
Molecular function	• molecular function;
Cellular component	• mitochondrial membranes; • integral component of membrane; • membrane; • mitochondrion; • endoplasmic reticulum; • endoplasmic reticulum membrane;
Biological process	• apoptotic process; • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; • negative regulation of toll-like receptor 9 signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	23151
	223752
	ENSG00000075240
	ENSMUSG00000035900
	Q6IC98
	Q8CB44
	NM_015124; NM_001366660
	NM_001205353; NM_172611; NM_001379572
	NP_055939; NP_001353589
	NP_001192282; NP_766199; NP_001366501
	Wikidata
View/Edit Human	View/Edit Mouse

GRAM domain containing 4 (GRAMD4) also known as Death-Inducing Protein (DIP) is a protein that is encoded by the GRAMD4 gene.[5][6]

Function

GRAMD4 is a mitochondrial effector of E2F1 (MIM 189971)-induced apoptosis.[7]

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References

GRCh38: Ensembl release 89: ENSG00000075240 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000035900 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: GRAM domain containing 4". Retrieved 2017-05-16.
"RecName: Full=GRAM domain-containing protein 4; AltName: Full=Death-inducing protein". Retrieved 2020-03-07.
Stanelle J, Tu-Rapp H, Pützer BM (2005). "A novel mitochondrial protein DIP mediates E2F1-induced apoptosis independently of p53". Cell Death Differ. 12 (4): 347–57. doi:10.1038/sj.cdd.4401532. PMID 15565177.

Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
John K, Alla V, Meier C, Pützer BM (2011). "GRAMD4 mimics p53 and mediates the apoptotic function of p73 at mitochondria". Cell Death Differ. 18 (5): 874–86. doi:10.1038/cdd.2010.153. PMC 3131914. PMID 21127500.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000075240 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000035900 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: GRAM domain containing 4". Retrieved 2017-05-16.

[6] "RecName: Full=GRAM domain-containing protein 4; AltName: Full=Death-inducing protein". Retrieved 2020-03-07.

[pmid16709157-7] Stanelle J, Tu-Rapp H, Pützer BM (2005). "A novel mitochondrial protein DIP mediates E2F1-induced apoptosis independently of p53". Cell Death Differ. 12 (4): 347–57. doi:10.1038/sj.cdd.4401532. PMID 15565177.

GRAMD4

Function

References

Further reading