GRAMD4

GRAMD4
Identifiers
Aliases	GRAMD4, DIP, dA59H18.1, dJ439F8.1, GRAM domain containing 4
External IDs	OMIM: 613691 MGI: 2676308 HomoloGene: 18199 GeneCards: GRAMD4
Gene location (Human)
Chr.	Chromosome 22 (human)[1]
End	46,679,790 bp[1]
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)[2]
End	86,137,634 bp[2]
Gene ontology
Molecular function	• molecular function;
Cellular component	• mitochondrial membranes; • integral component of membrane; • membrane; • mitochondrion; • endoplasmic reticulum; • endoplasmic reticulum membrane;
Biological process	• apoptotic process; • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; • negative regulation of toll-like receptor 9 signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	23151
	223752
	ENSG00000075240
	ENSMUSG00000035900
	Q6IC98
	Q8CB44
	NM_015124; NM_001366660
	NM_001205353; NM_172611; NM_001379572
	NP_055939; NP_001353589
	NP_001192282; NP_766199; NP_001366501
	Wikidata
View/Edit Human	View/Edit Mouse

GRAM domain containing 4 (GRAMD4) also known as Death-Inducing Protein (DIP) is a protein that is encoded by the GRAMD4 gene.[5][6]

Function

GRAMD4 is a mitochondrial effector of E2F1 (MIM 189971)-induced apoptosis.[7]

gollark: It's signalum cell frames and other random stuff. No titanium.

gollark: The AR gate quest barely gives you enough titanium and other stuff to, yes.

gollark: For a while after I got AE2 I had an extremely janky system using storage crates and a nested storage bus system to allow me to access all my storage through both.

gollark: Surprisingly good, especially with the infinite-range remote, but the UI is kind of terrible.

gollark: I lived on a storage scanner for several days.

References

GRCh38: Ensembl release 89: ENSG00000075240 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000035900 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: GRAM domain containing 4". Retrieved 2017-05-16.
"RecName: Full=GRAM domain-containing protein 4; AltName: Full=Death-inducing protein". Retrieved 2020-03-07.
Stanelle J, Tu-Rapp H, Pützer BM (2005). "A novel mitochondrial protein DIP mediates E2F1-induced apoptosis independently of p53". Cell Death Differ. 12 (4): 347–57. doi:10.1038/sj.cdd.4401532. PMID 15565177.

Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
John K, Alla V, Meier C, Pützer BM (2011). "GRAMD4 mimics p53 and mediates the apoptotic function of p73 at mitochondria". Cell Death Differ. 18 (5): 874–86. doi:10.1038/cdd.2010.153. PMC 3131914. PMID 21127500.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000075240 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000035900 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: GRAM domain containing 4". Retrieved 2017-05-16.

[6] "RecName: Full=GRAM domain-containing protein 4; AltName: Full=Death-inducing protein". Retrieved 2020-03-07.

[pmid16709157-7] Stanelle J, Tu-Rapp H, Pützer BM (2005). "A novel mitochondrial protein DIP mediates E2F1-induced apoptosis independently of p53". Cell Death Differ. 12 (4): 347–57. doi:10.1038/sj.cdd.4401532. PMID 15565177.

GRAMD4

Function

References

Further reading