GPRASP1

G-protein coupled receptor-associated sorting protein 1 is a protein that in humans is encoded by the GPRASP1 gene.[5][6][7]

GPRASP1
Identifiers
Aliases	GPRASP1, GASP, GASP-1, GASP1, G protein-coupled receptor associated sorting protein 1
External IDs	OMIM: 300417 MGI: 1917418 HomoloGene: 8809 GeneCards: GPRASP1
Gene location (Human) Chr. X chromosome (human)[1] Band Xq22.1 Start 102,651,092 bp[1] End 102,659,083 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X F1 Start 135,742,733 bp[2] End 135,803,474 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • cytoplasm • cytosol Biological process • G-protein coupled receptor catabolic process • endosome to lysosome transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9737	67298
Ensembl	ENSG00000198932	ENSMUSG00000043384
UniProt	Q5JY77	Q5U4C1
RefSeq (mRNA)	NM_014710 NM_001099410 NM_001099411 NM_001184727	NM_001004359 NM_001005385 NM_026081
RefSeq (protein)	NP_001092880 NP_001092881 NP_001171656 NP_055525	NP_001004359 NP_001005385 NP_080357
Location (UCSC)	Chr X: 102.65 – 102.66 Mb	Chr X: 135.74 – 135.8 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

GPRASP1 (gene) has been shown to interact with Delta Opioid receptor.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000198932 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000043384 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ishikawa K, Nagase T, Nakajima D, Seki N, Ohira M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (October 1997). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 4 (5): 307–13. doi:10.1093/dnares/4.5.307. PMID 9455477.
6. Simonin F, Karcher P, Boeuf JJ, Matifas A, Kieffer BL (May 2004). "Identification of a novel family of G protein-coupled receptor associated sorting proteins". Journal of Neurochemistry. 89 (3): 766–75. doi:10.1111/j.1471-4159.2004.02411.x. PMID 15086532.
7. "Entrez Gene: GPRASP1 G protein-coupled receptor associated sorting protein 1".
8. Whistler JL, Enquist J, Marley A, Fong J, Gladher F, Tsuruda P, Murray SR, Von Zastrow M (July 2002). "Modulation of postendocytic sorting of G protein-coupled receptors". Science. 297 (5581): 615–20. doi:10.1126/science.1073308. PMID 12142540.

Further reading

• Patrie KM, Drescher AJ, Goyal M, Wiggins RC, Margolis B (April 2001). "The membrane-associated guanylate kinase protein MAGI-1 binds megalin and is present in glomerular podocytes". Journal of the American Society of Nephrology. 12 (4): 667–77. PMID 11274227.
• Whistler JL, Enquist J, Marley A, Fong J, Gladher F, Tsuruda P, Murray SR, Von Zastrow M (July 2002). "Modulation of postendocytic sorting of G protein-coupled receptors". Science. 297 (5581): 615–20. doi:10.1126/science.1073308. PMID 12142540.
• Heydorn A, Søndergaard BP, Ersbøll B, Holst B, Nielsen FC, Haft CR, Whistler J, Schwartz TW (December 2004). "A library of 7TM receptor C-terminal tails. Interactions with the proposed post-endocytic sorting proteins ERM-binding phosphoprotein 50 (EBP50), N-ethylmaleimide-sensitive factor (NSF), sorting nexin 1 (SNX1), and G protein-coupled receptor-associated sorting protein (GASP)". The Journal of Biological Chemistry. 279 (52): 54291–303. doi:10.1074/jbc.M406169200. PMID 15452121.
• Bartlett SE, Enquist J, Hopf FW, Lee JH, Gladher F, Kharazia V, Waldhoer M, Mailliard WS, Armstrong R, Bonci A, Whistler JL (August 2005). "Dopamine responsiveness is regulated by targeted sorting of D2 receptors". Proceedings of the National Academy of Sciences of the United States of America. 102 (32): 11521–6. Bibcode:2005PNAS..10211521B. doi:10.1073/pnas.0502418102. PMC 1183554. PMID 16049099.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.