Glypican 6

Glypican-6 is a protein that in humans is encoded by the GPC6 gene.[4][5]

GPC6
Identifiers
Aliases	GPC6, OMIMD1, Glypican 6
External IDs	OMIM: 604404 MGI: 1346322 HomoloGene: 55922 GeneCards: GPC6
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q31.3-q32.1 Start 93,226,807 bp[1] End 94,408,020 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • heparan sulfate proteoglycan binding • coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway • GO:0001948 protein binding Cellular component • Golgi lumen • cell nucleus • integral component of plasma membrane • extracellular region • anchored component of membrane • proteinaceous extracellular matrix • lysosomal lumen • membrane • cell membrane • extracellular • anchored component of plasma membrane • collagen-containing extracellular matrix • glutamatergic synapse • cell surface • synapse Biological process • glycosaminoglycan metabolic process • retinoid metabolic process • cell migration • glycosaminoglycan biosynthetic process • glycosaminoglycan catabolic process • Wnt signaling pathway, planar cell polarity pathway • regulation of signal transduction • regulation of neurotransmitter receptor localization to postsynaptic specialization membrane • regulation of protein localization to membrane Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10082	23888
Ensembl	ENSG00000183098	n/a
UniProt	Q9Y625	Q9R087
RefSeq (mRNA)	NM_005708	NM_001079844 NM_011821
RefSeq (protein)	NP_005699	NP_001073313 NP_035951
Location (UCSC)	Chr 13: 93.23 – 94.41 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

The glypicans comprise a family of glycosylphosphatidylinositol-anchored heparan sulfate proteoglycans. The glypicans have been implicated in the control of cell growth and division. Glypican 6 is a putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases.[5]

See also

• Glypican

References

1. GRCh38: Ensembl release 89: ENSG00000183098 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Paine-Saunders S, Viviano BL, Saunders S (Aug 1999). "GPC6, a novel member of the glypican gene family, encodes a product structurally related to GPC4 and is colocalized with GPC5 on human chromosome 13". Genomics. 57 (3): 455–8. doi:10.1006/geno.1999.5793. PMID 10329016.
5. "Entrez Gene: GPC6 glypican 6".

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Veugelers M, De Cat B, Ceulemans H, et al. (1999). "Glypican-6, a new member of the glypican family of cell surface heparan sulfate proteoglycans". J. Biol. Chem. 274 (38): 26968–77. doi:10.1074/jbc.274.38.26968. PMID 10480909.
• Watanabe K, Yamada H, Yamaguchi Y (1995). "K-glypican: a novel GPI-anchored heparan sulfate proteoglycan that is highly expressed in developing brain and kidney". J. Cell Biol. 130 (5): 1207–18. doi:10.1083/jcb.130.5.1207. PMC 2120559. PMID 7657705.

External links

• GPC6 human gene location in the UCSC Genome Browser.
• GPC6 human gene details in the UCSC Genome Browser.