Glypican 5

Glypican-5 is a protein that in humans is encoded by the GPC5 gene.[5][6]

GPC5
Identifiers
Aliases	GPC5, glypican 5
External IDs	OMIM: 602446 MGI: 1194894 HomoloGene: 3285 GeneCards: GPC5
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q31.3 Start 91,398,621 bp[1] End 92,873,682 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 E4 Start 115,092,215 bp[2] End 116,525,179 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • heparan sulfate proteoglycan binding Cellular component • integral component of plasma membrane • extracellular region • membrane • anchored component of membrane • Golgi lumen • cell membrane • lysosomal lumen • extracellular • anchored component of plasma membrane • integral component of membrane • collagen-containing extracellular matrix • cell surface Biological process • glycosaminoglycan biosynthetic process • retinoid metabolic process • glycosaminoglycan catabolic process • regulation of signal transduction • cell migration • positive regulation of canonical Wnt signaling pathway • regulation of protein localization to membrane Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2262	103978
Ensembl	ENSG00000179399	ENSMUSG00000022112
UniProt	P78333	Q8CAL5
RefSeq (mRNA)	NM_004466	NM_175500
RefSeq (protein)	NP_004457	NP_780709
Location (UCSC)	Chr 13: 91.4 – 92.87 Mb	Chr 14: 115.09 – 116.53 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation.[6]

See also

• Glypican

References

1. GRCh38: Ensembl release 89: ENSG00000179399 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022112 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Veugelers M, Vermeesch J, Reekmans G, Steinfeld R, Marynen P, David G (Jun 1997). "Characterization of glypican-5 and chromosomal localization of human GPC5, a new member of the glypican gene family". Genomics. 40 (1): 24–30. doi:10.1006/geno.1996.4518. PMID 9070915.
6. "Entrez Gene: GPC5 glypican 5".

Further reading

• De Cat B, David G (2001). "Developmental roles of the glypicans". Semin. Cell Dev. Biol. 12 (2): 117–25. doi:10.1006/scdb.2000.0240. PMID 11292377.
• Watanabe K, Yamada H, Yamaguchi Y (1995). "K-glypican: a novel GPI-anchored heparan sulfate proteoglycan that is highly expressed in developing brain and kidney". J. Cell Biol. 130 (5): 1207–18. doi:10.1083/jcb.130.5.1207. PMC 2120559. PMID 7657705.
• Saunders S, Paine-Saunders S, Lander AD (1997). "Expression of the cell surface proteoglycan glypican-5 is developmentally regulated in kidney, limb, and brain" (PDF). Dev. Biol. 190 (1): 78–93. doi:10.1006/dbio.1997.8690. PMID 9331333.
• Veugelers M, De Cat B, Delande N, et al. (2002). "A 4-Mb BAC/PAC contig and complete genomic structure of the GPC5/GPC6 gene cluster on chromosome 13q32". Matrix Biol. 20 (5–6): 375–85. doi:10.1016/S0945-053X(01)00143-3. PMID 11566272.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Yu W, Inoue J, Imoto I, et al. (2004). "GPC5 is a possible target for the 13q31-q32 amplification detected in lymphoma cell lines". J. Hum. Genet. 48 (6): 331–5. doi:10.1007/s10038-003-0026-2. PMID 12721791.
• Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.