Glypican 4

Glypican-4 is a protein that in humans is encoded by the GPC4 gene.[5][6]

GPC4
Identifiers
Aliases	GPC4, K-glypican, glypican 4, KPTS
External IDs	OMIM: 300168 MGI: 104902 HomoloGene: 55582 GeneCards: GPC4
Gene location (Human) Chr. X chromosome (human)[1] Band Xq26.2 Start 133,300,103 bp[1] End 133,415,489 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X A5|X 28.33 cM Start 52,053,021 bp[2] End 52,165,252 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • heparan sulfate proteoglycan binding • coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway Cellular component • membrane • proteinaceous extracellular matrix • cell membrane • integral component of plasma membrane • extracellular region • lysosomal lumen • Golgi lumen • anchored component of membrane • extracellular exosome • external side of plasma membrane • cell nucleus • extracellular • synapse • anchored component of plasma membrane • collagen-containing extracellular matrix • glutamatergic synapse • anchored component of presynaptic membrane • cell surface Biological process • glycosaminoglycan metabolic process • anatomical structure morphogenesis • retinoid metabolic process • glycosaminoglycan catabolic process • glycosaminoglycan biosynthetic process • cellular proliferation • Wnt signaling pathway, planar cell polarity pathway • regulation of signal transduction • regulation of neurotransmitter receptor localization to postsynaptic specialization membrane • synaptic membrane adhesion • regulation of presynapse assembly • cell migration • regulation of protein localization to membrane Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2239	14735
Ensembl	ENSG00000076716	ENSMUSG00000031119
UniProt	O75487	P51655
RefSeq (mRNA)	NM_001448	NM_008150
RefSeq (protein)	NP_001439	NP_032176
Location (UCSC)	Chr X: 133.3 – 133.42 Mb	Chr X: 52.05 – 52.17 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The GPC4 gene is adjacent to the 3' end of GPC3 and may also play a role in Simpson-Golabi-Behmel syndrome.[6]

See also

• Glypican

References

1. GRCh38: Ensembl release 89: ENSG00000076716 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031119 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Veugelers M, Vermeesch J, Watanabe K, Yamaguchi Y, Marynen P, David G (October 1998). "GPC4, the gene for human K-glypican, flanks GPC3 on xq26: deletion of the GPC3-GPC4 gene cluster in one family with Simpson-Golabi-Behmel syndrome". Genomics. 53 (1): 1–11. doi:10.1006/geno.1998.5465. PMID 9787072.
6. "Entrez Gene: GPC4 glypican 4".

Further reading

• Sheu TJ, Schwarz EM, O'Keefe RJ, Rosier RN, Puzas JE (May 2002). "Use of a phage display technique to identify potential osteoblast binding sites within osteoclast lacunae". Journal of Bone and Mineral Research. 17 (5): 915–22. doi:10.1359/jbmr.2002.17.5.915. PMID 12009023.
• Karumanchi SA, Jha V, Ramchandran R, Karihaloo A, Tsiokas L, Chan B, Dhanabal M, Hanai JI, Venkataraman G, Shriver Z, Keiser N, Kalluri R, Zeng H, Mukhopadhyay D, Chen RL, Lander AD, Hagihara K, Yamaguchi Y, Sasisekharan R, Cantley L, Sukhatme VP (April 2001). "Cell surface glypicans are low-affinity endostatin receptors" (PDF). Molecular Cell. 7 (4): 811–22. doi:10.1016/S1097-2765(01)00225-8. PMID 11336704.
• Hagihara K, Watanabe K, Chun J, Yamaguchi Y (November 2000). "Glypican-4 is an FGF2-binding heparan sulfate proteoglycan expressed in neural precursor cells". Developmental Dynamics. 219 (3): 353–67. doi:10.1002/1097-0177(2000)9999:9999<::AID-DVDY1059>3.0.CO;2-#. PMID 11066092.
• Veugelers M, Cat BD, Muyldermans SY, Reekmans G, Delande N, Frints S, Legius E, Fryns JP, Schrander-Stumpel C, Weidle B, Magdalena N, David G (May 2000). "Mutational analysis of the GPC3/GPC4 glypican gene cluster on Xq26 in patients with Simpson-Golabi-Behmel syndrome: identification of loss-of-function mutations in the GPC3 gene". Human Molecular Genetics. 9 (9): 1321–8. doi:10.1093/hmg/9.9.1321. PMID 10814714.
• Siebertz B, Stöcker G, Drzeniek Z, Handt S, Just U, Haubeck HD (December 1999). "Expression of glypican-4 in haematopoietic-progenitor and bone-marrow-stromal cells". The Biochemical Journal. 344. 344 Pt 3: 937–43. PMC 1220719. PMID 10585884.
• Huber R, Mazzarella R, Chen CN, Chen E, Ireland M, Lindsay S, Pilia G, Crisponi L (December 1998). "Glypican 3 and glypican 4 are juxtaposed in Xq26.1". Gene. 225 (1–2): 9–16. doi:10.1016/S0378-1119(98)00549-6. PMID 9931407.
• Watanabe K, Yamada H, Yamaguchi Y (September 1995). "K-glypican: a novel GPI-anchored heparan sulfate proteoglycan that is highly expressed in developing brain and kidney". The Journal of Cell Biology. 130 (5): 1207–18. doi:10.1083/jcb.130.5.1207. PMC 2120559. PMID 7657705.

External links

• GeneReviews/NIH/NCBI/UW entry on Simpson-Golabi-Behmel Syndrome