GPA33

Cell surface A33 antigen is a protein that in humans is encoded by the GPA33 gene.[5][6][7]

GPA33
Identifiers
AliasesGPA33, A33, glycoprotein A33
External IDsOMIM: 602171 MGI: 1891703 HomoloGene: 4245 GeneCards: GPA33
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1q24.1Start167,052,836 bp[1]
End167,166,479 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

10223

59290

Ensembl

ENSG00000143167

ENSMUSG00000000544

UniProt

Q99795

Q9JKA5

RefSeq (mRNA)

NM_005814

NM_021610
NM_001360925
NM_001360926

RefSeq (protein)

NP_005805

NP_067623
NP_001347854
NP_001347855

Location (UCSC)Chr 1: 167.05 – 167.17 MbChr 1: 166.13 – 166.17 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The glycoprotein encoded by this gene is a cell surface antigen that is expressed in greater than 95% of human colon cancers. The open reading frame encodes a 319-amino acid polypeptide having a putative secretory signal sequence and 3 potential glycosylation sites. The predicted mature protein has a 213-amino acid extracellular region, a single transmembrane domain, and a 62-amino acid intracellular tail. The sequence of the extracellular region contains 2 domains characteristic of the CD2 subgroup of the immunoglobulin (Ig) superfamily.[7]

References
  1. GRCh38: Ensembl release 89: ENSG00000143167 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000000544 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Heath JK, White SJ, Johnstone CN, Catimel B, Simpson RJ, Moritz RL, Tu GF, Ji H, Whitehead RH, Groenen LC, Scott AM, Ritter G, Cohen L, Welt S, Old LJ, Nice EC, Burgess AW (Mar 1997). "The human A33 antigen is a transmembrane glycoprotein and a novel member of the immunoglobulin superfamily". Proc Natl Acad Sci U S A. 94 (2): 469–74. Bibcode:1997PNAS...94..469H. doi:10.1073/pnas.94.2.469. PMC 19536. PMID 9012807.
  6. Ritter G, Cohen LS, Nice EC, Catimel B, Burgess AW, Moritz RL, Ji H, Heath JK, White SJ, Welt S, Old LJ, Simpson RJ (Sep 1997). "Characterization of posttranslational modifications of human A33 antigen, a novel palmitoylated surface glycoprotein of human gastrointestinal epithelium". Biochem Biophys Res Commun. 236 (3): 682–6. doi:10.1006/bbrc.1997.6966. PMID 9245713.
  7. "Entrez Gene: GPA33 glycoprotein A33 (transmembrane)".

Further reading


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