GMDS (gene)

GDP-mannose 4,6 dehydratase is an enzyme that in humans is encoded by the GMDS gene.[5][6][7]

GMDS
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1T2A
Identifiers
Aliases	GMDS, GMD, SDR3E1, GDP-mannose 4,6-dehydratase
External IDs	OMIM: 602884 MGI: 1891112 HomoloGene: 75968 GeneCards: GMDS
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p25.3 Start 1,623,806 bp[1] End 2,245,605 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 A3.2 Start 31,819,579 bp[2] End 32,338,740 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • NADP+ binding • lyase activity • GDP-mannose 4,6-dehydratase activity • identical protein binding Cellular component • cytosol • extracellular exosome • cytoplasm Biological process • GDP-mannose metabolic process • 'de novo' GDP-L-fucose biosynthetic process • Notch signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2762	218138
Ensembl	ENSG00000112699	ENSMUSG00000038372
UniProt	O60547	Q8K0C9
RefSeq (mRNA)	NM_001253846 NM_001500	NM_146041
RefSeq (protein)	NP_001240775 NP_001491	NP_666153
Location (UCSC)	Chr 6: 1.62 – 2.25 Mb	Chr 13: 31.82 – 32.34 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000112699 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038372 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Sullivan FX, Kumar R, Kriz R, Stahl M, Xu GY, Rouse J, Chang XJ, Boodhoo A, Potvin B, Cumming DA (May 1998). "Molecular cloning of human GDP-mannose 4,6-dehydratase and reconstitution of GDP-fucose biosynthesis in vitro". J Biol Chem. 273 (14): 8193–8202. doi:10.1074/jbc.273.14.8193. PMID 9525924.
6. Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative". Chem Biol Interact. 178 (1–3): 94–98. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.
7. "Entrez Gene: GMDS GDP-mannose 4,6-dehydratase".

Further reading

• Ohyama C, Smith PL, Angata K, et al. (1998). "Molecular cloning and expression of GDP-D-mannose-4,6-dehydratase, a key enzyme for fucose metabolism defective in Lec13 cells". J. Biol. Chem. 273 (23): 14582–14587. doi:10.1074/jbc.273.23.14582. PMID 9603974.
• Roos C, Kolmer M, Mattila P, Renkonen R (2002). "Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism". J. Biol. Chem. 277 (5): 3168–3175. doi:10.1074/jbc.M107927200. PMID 11698403.
• Eshel R, Besser M, Zanin A, et al. (2002). "The FX enzyme is a functional component of lymphocyte activation". Cell. Immunol. 213 (2): 141–148. doi:10.1006/cimm.2001.1872. PMID 11831876.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–811. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.