GMCL1

Germ cell-less, spermatogenesis associated 1 is a protein that in humans is encoded by the GMCL1 gene. [5]

GMCL1
Identifiers
Aliases	GMCL1, BTBD13, GCL, GCL1, SPATA29, germ cell-less, spermatogenesis associated 1, germ cell-less 1, spermatogenesis associated
External IDs	MGI: 1345156 HomoloGene: 8021 GeneCards: GMCL1
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p13.3 Start 69,829,660 bp[1] End 69,881,384 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 D1|6 37.75 cM Start 86,691,768 bp[2] End 86,733,383 bp[2]
Gene ontology Molecular function • GO:0001948 protein binding • identical protein binding Cellular component • nuclear matrix • nuclear envelope • ubiquitin ligase complex • cell nucleus Biological process • multicellular organism development • cell differentiation • regulation of transcription, DNA-templated • spermatogenesis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	64395	23885
Ensembl	ENSG00000087338	ENSMUSG00000001157
UniProt	Q96IK5	Q920G9
RefSeq (mRNA)	NM_178439	NM_011818
RefSeq (protein)	NP_848526	NP_035948
Location (UCSC)	Chr 2: 69.83 – 69.88 Mb	Chr 6: 86.69 – 86.73 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a nuclear envelope protein that appears to be involved in spermatogenesis, either directly or by influencing genes that play a more direct role in the process. This multi-exon locus is the homolog of the mouse and drosophila germ cell-less gene but the human genome also contains a single-exon locus on chromosome 5 that contains an open reading frame capable of encoding a highly related protein.

References

1. GRCh38: Ensembl release 89: ENSG00000087338 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000001157 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Germ cell-less, spermatogenesis associated 1". Retrieved 2015-09-17.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.