GINS2

DNA replication complex GINS protein PSF2 is a protein that in humans is encoded by the GINS2 gene.[4][5][6]

GINS2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2E9X, 2EHO, 2Q9Q
Identifiers
Aliases	GINS2, HSPC037, PSF2, Pfs2, GINS complex subunit 2
External IDs	OMIM: 610609 MGI: 1921019 HomoloGene: 41105 GeneCards: GINS2
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q24.1 Start 85,676,198 bp[1] End 85,690,073 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0043140 3'-5' DNA helicase activity • GO:0001948 protein binding Cellular component • GINS complex • replication fork protection complex • cell nucleus • nucleoplasm Biological process • DNA replication • DNA strand elongation involved in DNA replication • double-strand break repair via break-induced replication • mitotic DNA replication initiation • DNA duplex unwinding Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51659	272551
Ensembl	ENSG00000131153	n/a
UniProt	Q9Y248	Q9D600
RefSeq (mRNA)	NM_016095	NM_178856
RefSeq (protein)	NP_057179	NP_849187
Location (UCSC)	Chr 16: 85.68 – 85.69 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

GINS2 has been shown to interact with CHEK2.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000131153 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
5. Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (Aug 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
6. "Entrez Gene: GINS2 GINS complex subunit 2 (Psf2 homolog)".
7. Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER, Hurov KE, Luo J, Bakalarski CE, Zhao Z, Solimini N, Lerenthal Y, Shiloh Y, Gygi SP, Elledge SJ (May 2007). "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage". Science. 316 (5828): 1160–6. doi:10.1126/science.1140321. PMID 17525332.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Takayama Y, Kamimura Y, Okawa M, Muramatsu S, Sugino A, Araki H (2003). "GINS, a novel multiprotein complex required for chromosomal DNA replication in budding yeast". Genes Dev. 17 (9): 1153–65. doi:10.1101/gad.1065903. PMC 196052. PMID 12730134.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER, Hurov KE, Luo J, Bakalarski CE, Zhao Z, Solimini N, Lerenthal Y, Shiloh Y, Gygi SP, Elledge SJ (2007). "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage". Science. 316 (5828): 1160–6. doi:10.1126/science.1140321. PMID 17525332.