GFI1B

Zinc finger protein Gfi-1b is a protein that in humans is encoded by the GFI1B gene.[5][6]

GFI1B
Identifiers
Aliases	GFI1B, BDPLT17, ZNF163B, growth factor independent 1B transcriptional repressor
External IDs	OMIM: 604383 MGI: 1276578 HomoloGene: 31223 GeneCards: GFI1B
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q34.13 Start 132,944,000 bp[1] End 132,991,687 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 A3 Start 28,609,450 bp[2] End 28,621,982 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • GO:0001948 protein binding • metal ion binding • RNA polymerase II transcription factor binding • nucleic acid binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • nuclear matrix • cell nucleus • transcription factor complex Biological process • multicellular organism development • cellular proliferation • regulation of transcription, DNA-templated • negative regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • transcription, DNA-templated • chromatin organization • negative regulation of G1/S transition of mitotic cell cycle Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8328	14582
Ensembl	ENSG00000165702	ENSMUSG00000026815
UniProt	Q5VTD9	O70237
RefSeq (mRNA)	NM_001135031 NM_004188 NM_001371908 NM_001377304 NM_001377305	NM_001160406 NM_008114
RefSeq (protein)	NP_001128503 NP_004179 NP_001358837 NP_001364233 NP_001364234	NP_001153878 NP_032140
Location (UCSC)	Chr 9: 132.94 – 132.99 Mb	Chr 2: 28.61 – 28.62 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000165702 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026815 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Rodel B, Wagner T, Zornig M, Niessing J, Moroy T (Feb 1999). "The human homologue (GFI1B) of the chicken GFI gene maps to chromosome 9q34.13-A locus frequently altered in hematopoietic diseases". Genomics. 54 (3): 580–2. doi:10.1006/geno.1998.5601. PMID 9878267.
6. "Entrez Gene: GFI1B growth factor independent 1B (potential regulator of CDKN1A, translocated in CML)".

Further reading

• Tong B, Grimes HL, Yang TY, et al. (1998). "The Gfi-1B proto-oncoprotein represses p21WAF1 and inhibits myeloid cell differentiation". Mol. Cell. Biol. 18 (5): 2462–73. PMC 110626. PMID 9566867.
• Osawa M, Yamaguchi T, Nakamura Y, et al. (2002). "Erythroid expansion mediated by the Gfi-1B zinc finger protein: role in normal hematopoiesis". Blood. 100 (8): 2769–77. doi:10.1182/blood-2002-01-0182. PMID 12351384.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Huang DY, Kuo YY, Lai JS, et al. (2004). "GATA-1 and NF-Y cooperate to mediate erythroid-specific transcription of Gfi-1B gene". Nucleic Acids Res. 32 (13): 3935–46. doi:10.1093/nar/gkh719. PMC 506805. PMID 15280509.
• Garçon L, Lacout C, Svinartchouk F, et al. (2005). "Gfi-1B plays a critical role in terminal differentiation of normal and transformed erythroid progenitor cells". Blood. 105 (4): 1448–55. doi:10.1182/blood-2003-11-4068. PMID 15507521.
• Huang DY, Kuo YY, Chang ZF (2005). "GATA-1 mediates auto-regulation of Gfi-1B transcription in K562 cells". Nucleic Acids Res. 33 (16): 5331–42. doi:10.1093/nar/gki838. PMC 1226314. PMID 16177182.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
• Xu W, Kee BL (2007). "Growth factor independent 1B (Gfi1b) is an E2A target gene that modulates Gata3 in T-cell lymphomas". Blood. 109 (10): 4406–14. doi:10.1182/blood-2006-08-043331. PMID 17272506.
• Kuo YY, Chang ZF (2007). "GATA-1 and Gfi-1B interplay to regulate Bcl-xL transcription". Mol. Cell. Biol. 27 (12): 4261–72. doi:10.1128/MCB.02212-06. PMC 1900040. PMID 17420275.