GCC2

GRIP and coiled-coil domain-containing protein 2 is a protein that in humans is encoded by the GCC2 gene.[4][5]

GCC2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3BBP
Identifiers
Aliases	GCC2, GCC185, RANBP2L4, REN53, GRIP and coiled-coil domain containing 2
External IDs	OMIM: 612711 MGI: 1917547 HomoloGene: 45639 GeneCards: GCC2
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q12.3 Start 108,449,191 bp[1] End 108,509,415 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • identical protein binding Cellular component • cytoplasm • trans-Golgi network • Golgi apparatus • membrane • cytosol • nucleoplasm Biological process • Golgi to plasma membrane protein transport • protein transport • microtubule anchoring • protein targeting to lysosome • retrograde transport, endosome to Golgi • late endosome to Golgi transport • regulation of protein exit from endoplasmic reticulum • microtubule organizing center organization • recycling endosome to Golgi transport • Golgi ribbon formation • protein localization to Golgi apparatus • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9648	70297
Ensembl	ENSG00000135968	n/a
UniProt	Q8IWJ2	Q8CHG3
RefSeq (mRNA)	NM_181453	NM_027375
RefSeq (protein)	NP_852118	n/a
Location (UCSC)	Chr 2: 108.45 – 108.51 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a peripheral membrane protein localized to the trans-Golgi network. It is sensitive to brefeldin A. This encoded protein contains a GRIP domain which is thought to be used in targeting. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000135968 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Luke MR, Kjer-Nielsen L, Brown DL, Stow JL, Gleeson PA (Feb 2003). "GRIP domain-mediated targeting of two new coiled-coil proteins, GCC88 and GCC185, to subcompartments of the trans-Golgi network". J Biol Chem. 278 (6): 4216–26. doi:10.1074/jbc.M210387200. PMID 12446665.
5. "Entrez Gene: GCC2 GRIP and coiled-coil domain containing 2".

Further reading

• Derby MC, Lieu ZZ, Brown D, et al. (2007). "The trans-Golgi network golgin, GCC185, is required for endosome-to-Golgi transport and maintenance of Golgi structure". Traffic. 8 (6): 758–73. doi:10.1111/j.1600-0854.2007.00563.x. PMID 17488291.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
• Reddy JV, Burguete AS, Sridevi K, et al. (2007). "A Functional Role for the GCC185 Golgin in Mannose 6-Phosphate Receptor Recycling". Mol. Biol. Cell. 17 (10): 4353–63. doi:10.1091/mbc.E06-02-0153. PMC 1635343. PMID 16885419.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
• Luke MR, Houghton F, Perugini MA, Gleeson PA (2005). "The trans-Golgi network GRIP-domain proteins form α-helical homodimers". Biochem. J. 388 (Pt 3): 835–41. doi:10.1042/BJ20041810. PMC 1183463. PMID 15654769.
• Derby MC, van Vliet C, Brown D, et al. (2005). "Mammalian GRIP domain proteins differ in their membrane binding properties and are recruited to distinct domains of the TGN". J. Cell Sci. 117 (Pt 24): 5865–74. doi:10.1242/jcs.01497. PMID 15522892.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Lu L, Hong W (2004). "Interaction of Arl1-GTP with GRIP Domains Recruits Autoantigens Golgin-97 and Golgin-245/p230 onto the Golgi". Mol. Biol. Cell. 14 (9): 3767–81. doi:10.1091/mbc.E03-01-0864. PMC 196566. PMID 12972563.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Krackhardt AM, Witzens M, Harig S, et al. (2002). "Identification of tumor-associated antigens in chronic lymphocytic leukemia by SEREX". Blood. 100 (6): 2123–31. doi:10.1182/blood-2002-02-0513. PMID 12200376.
• Eichmuller S, Usener D, Dummer R, et al. (2001). "Serological detection of cutaneous T-cell lymphoma-associated antigens". Proc. Natl. Acad. Sci. U.S.A. 98 (2): 629–34. doi:10.1073/pnas.021386498. PMC 14639. PMID 11149944.
• Scanlan MJ, Gordan JD, Williamson B, et al. (1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". Int. J. Cancer. 83 (4): 456–64. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID 10508479.
• Nagase T, Ishikawa K, Nakajima D, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841.