GAPVD1

GTPase activating protein and VPS9 domains 1, also known as GAPVD1, Gapex-5 and RME-6 is a protein which in humans is encoded by the GAPVD1 gene.[5][6]

GAPVD1
Identifiers
AliasesGAPVD1, GAPEX5, GAPex-5, RAP6, GTPase activating protein and VPS9 domains 1
External IDsOMIM: 611714 MGI: 1913941 HomoloGene: 32637 GeneCards: GAPVD1
Gene location (Human)
Chr.Chromosome 9 (human)[1]
Band9q33.3Start125,261,794 bp[1]
End125,367,207 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

26130

66691

Ensembl

ENSG00000165219

ENSMUSG00000026867

UniProt

Q14C86

Q6PAR5

RefSeq (mRNA)

NM_025709
NM_001356441

RefSeq (protein)

NP_079985
NP_001343370

Location (UCSC)Chr 9: 125.26 – 125.37 MbChr 2: 34.67 – 34.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

GAPVD1 is Rab GTPase guanine nucleotide exchange factor essential for activation of RAB5A during engulfment of apoptotic cells.[7] GAPVD1 is also involved in the degradation of the epidermal growth factor receptor.[8] Gapex-5 mediated activation of Rab5 has been implicated in the insulin stimulated formation of plasma membrane phosphatidylinositol-3-phosphate.[9]

Structure

Based on sequence homology, mammalian Gapex-5 has been shown to have an amino-terminal Ras GAP domain, a central polyproline (SH3 binding) region and a carboxy-terminal Rab GEF domain. The RabGEF domain has been suggested to activate Rab5[10] and Rab31.[11]

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References
  1. GRCh38: Ensembl release 89: ENSG00000165219 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000026867 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: GAPVD1 GTPase activating protein and VPS9 domains 1".
  6. Hunker CM, Galvis A, Kruk I, Giambini H, Veisaga ML, Barbieri MA (February 2006). "Rab5-activating protein 6, a novel endosomal protein with a role in endocytosis". Biochem. Biophys. Res. Commun. 340 (3): 967–75. doi:10.1016/j.bbrc.2005.12.099. PMID 16410077.
  7. Kitano M, Nakaya M, Nakamura T, Nagata S, Matsuda M (May 2008). "Imaging of Rab5 activity identifies essential regulators for phagosome maturation". Nature. 453 (7192): 241–5. doi:10.1038/nature06857. PMID 18385674.
  8. Su X, Kong C, Stahl PD (July 2007). "GAPex-5 mediates ubiquitination, trafficking, and degradation of epidermal growth factor receptor". J. Biol. Chem. 282 (29): 21278–84. doi:10.1074/jbc.M703725200. PMID 17545148.
  9. Lodhi IJ, Bridges D, Chiang SH, Zhang Y, Cheng A, Geletka LM, Weisman LS, Saltiel AR (July 2008). "Insulin Stimulates Phosphatidylinositol 3-Phosphate Production via the Activation of Rab5". Mol. Biol. Cell. 19 (7): 2718–28. doi:10.1091/mbc.E08-01-0105. PMC 2441665. PMID 18434594.
  10. Su X, Lodhi IJ, Saltiel AR, Stahl PD (September 2006). "Insulin-stimulated Interaction between insulin receptor substrate 1 and p85alpha and activation of protein kinase B/Akt require Rab5". J. Biol. Chem. 281 (38): 27982–90. doi:10.1074/jbc.M602873200. PMID 16880210.
  11. Lodhi IJ, Chiang SH, Chang L, Vollenweider D, Watson RT, Inoue M, Pessin JE, Saltiel AR (January 2007). "Gapex-5, a Rab31 Guanine Nucleotide Exchange Factor that Regulates Glut4 Trafficking in Adipocytes". Cell Metab. 5 (1): 59–72. doi:10.1016/j.cmet.2006.12.006. PMC 1779820. PMID 17189207.

Further reading


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