GALNT13

Polypeptide N-acetylgalactosaminyltransferase 13 is an enzyme that in humans is encoded by the GALNT13 gene.[5][6][7]

GALNT13
Identifiers
Aliases	GALNT13, GalNAc-T13, polypeptide N-acetylgalactosaminyltransferase 13
External IDs	OMIM: 608369 MGI: 2139447 HomoloGene: 62167 GeneCards: GALNT13
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q23.3-q24.1 Start 153,871,922 bp[1] End 154,453,979 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 C1.1 Start 54,436,317 bp[2] End 55,118,309 bp[2]
Gene ontology Molecular function • transferase activity, transferring glycosyl groups • transferase activity • metal ion binding • carbohydrate binding • polypeptide N-acetylgalactosaminyltransferase activity Cellular component • integral component of membrane • Golgi membrane • Golgi apparatus • membrane Biological process • protein glycosylation • O-glycan processing • protein O-linked glycosylation • protein O-linked glycosylation via serine • protein O-linked glycosylation via threonine Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	114805	271786
Ensembl	ENSG00000144278	ENSMUSG00000060988
UniProt	Q8IUC8	Q8CF93
RefSeq (mRNA)	NM_001301627 NM_052917	NM_173030
RefSeq (protein)	NP_001288556 NP_443149 NP_001363321 NP_001363323 NP_001363327 NP_001363329 NP_001363330 NP_001363331 NP_001363332 NP_001363333 NP_001363334	NP_766618
Location (UCSC)	Chr 2: 153.87 – 154.45 Mb	Chr 2: 54.44 – 55.12 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The GALNT13 protein is a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAcT; EC 2.4.1.41) family, which initiate O-linked glycosylation of mucins (see MUC3A, MIM 158371) by the initial transfer of N-acetylgalactosamine (GalNAc) with an alpha-linkage to a serine or threonine residue.[supplied by OMIM][7]

References

1. GRCh38: Ensembl release 89: ENSG00000144278 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000060988 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Kikuno R, Ohara O (Sep 2001). "Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins". DNA Res. 8 (4): 179–87. doi:10.1093/dnares/8.4.179. PMID 11572484.
6. Zhang Y, Iwasaki H, Wang H, Kudo T, Kalka TB, Hennet T, Kubota T, Cheng L, Inaba N, Gotoh M, Togayachi A, Guo J, Hisatomi H, Nakajima K, Nishihara S, Nakamura M, Marth JD, Narimatsu H (Dec 2002). "Cloning and characterization of a new human UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase, designated pp-GalNAc-T13, that is specifically expressed in neurons and synthesizes GalNAc alpha-serine/threonine antigen". J Biol Chem. 278 (1): 573–84. doi:10.1074/jbc.M203094200. PMID 12407114.
7. "Entrez Gene: GALNT13 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13 (GalNAc-T13)".

Further reading

• "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. 1999. doi:10.1101/gr.8.11.1097. PMID 9847074.
• Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
• Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.