GAL3ST3

Galactose-3-O-sulfotransferase 3 is an enzyme that in humans is encoded by the GAL3ST3 gene.[5][6][7]

GAL3ST3
Identifiers
Aliases	GAL3ST3, GAL3ST-3, GAL3ST2, galactose-3-O-sulfotransferase 3
External IDs	OMIM: 608234 MGI: 3617843 HomoloGene: 57198 GeneCards: GAL3ST3
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.1 Start 66,040,765 bp[1] End 66,049,161 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 A Start 5,298,331 bp[2] End 5,308,738 bp[2]
Gene ontology Molecular function • galactose 3-O-sulfotransferase activity • transferase activity • galactosylceramide sulfotransferase activity • proteoglycan sulfotransferase activity • 3'-phosphoadenosine 5'-phosphosulfate binding • carbohydrate binding Cellular component • integral component of membrane • Golgi cisterna membrane • Golgi apparatus • membrane Biological process • glycolipid biosynthetic process • sulfur compound metabolic process • poly-N-acetyllactosamine metabolic process • oligosaccharide metabolic process • proteoglycan biosynthetic process • monosaccharide metabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	89792	545276
Ensembl	ENSG00000175229	ENSMUSG00000047658
UniProt	Q96A11	P61315
RefSeq (mRNA)	NM_033036	NM_001024717
RefSeq (protein)	NP_149025	NP_001019888
Location (UCSC)	Chr 11: 66.04 – 66.05 Mb	Chr 19: 5.3 – 5.31 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of the galactose-3-O-sulfotransferase protein family. The product of this gene catalyzes sulfonation by transferring a sulfate group to the 3' position of galactose in N-acetyllactosamine in both type 2 (Gal-beta-1-4GlcNAc-R) oligosaccharides and core-2-branched O-glycans, but not on type 1 or core-1-branched structures. This gene, which has also been referred to as GAL3ST2, is different from the GAL3ST2 gene located on chromosome 2 that encodes a related enzyme with distinct tissue distribution and substrate specificities, compared to galactose-3-O-sulfotransferase 3.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000175229 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000047658 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Suzuki A, Hiraoka N, Suzuki M, Angata K, Misra AK, McAuliffe J, Hindsgaul O, Fukuda M (Jun 2001). "Molecular cloning and expression of a novel human beta-Gal-3-O-sulfotransferase that acts preferentially on N-acetyllactosamine in N- and O-glycans". J Biol Chem. 276 (26): 24388–95. doi:10.1074/jbc.M103135200. PMID 11323440.
6. El-Fasakhany FM, Uchimura K, Kannagi R, Muramatsu T (Jul 2001). "A novel human Gal-3-O-sulfotransferase: molecular cloning, characterization, and its implications in biosynthesis of (SO(4)-3)Galbeta1-4(Fucalpha1-3)GlcNAc". J Biol Chem. 276 (29): 26988–94. doi:10.1074/jbc.M100348200. PMID 11356829.
7. "Entrez Gene: GAL3ST3 galactose-3-O-sulfotransferase 3".

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Chandrasekaran EV, Lakhaman SS, Chawda R, et al. (2004). "Identification of physiologically relevant substrates for cloned Gal: 3-O-sulfotransferases (Gal3STs): distinct high affinity of Gal3ST-2 and LS180 sulfotransferase for the globo H backbone, Gal3ST-3 for N-glycan multiterminal Galbeta1, 4GlcNAcbeta units and 6-sulfoGalbeta1, 4GlcNAcbeta, and Gal3ST-4 for the mucin core-2 trisaccharide". J. Biol. Chem. 279 (11): 10032–41. doi:10.1074/jbc.M311989200. PMID 14701868.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Seko A, Hara-Kuge S, Yamashita K (2001). "Molecular cloning and characterization of a novel human galactose 3-O-sulfotransferase that transfers sulfate to gal beta 1-->3galNAc residue in O-glycans". J. Biol. Chem. 276 (28): 25697–704. doi:10.1074/jbc.M101558200. PMID 11333265.
• Chandrasekaran EV, Jain RK, Rhodes JM, et al. (2000). "Characterization of distinct Gal:3-O-sulfotransferase activities in human tumor epithelial cell lines and of calf lymph node GlcNAc : 6-O-sulfotransferase activity". Glycoconj. J. 16 (9): 523–36. doi:10.1023/A:1007074005371. PMID 10815989.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.